Hemodynamic and electrocardiographic effects of fructose-1,6-diphosphate in acute myocardial infarction |
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| Authors: | N Marchionni A Conti W De Alfieri M Di Bari L Ferrucci A Lombardi G Moschi R Pini A Vannucci |
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| Affiliation: | 1. Department of Biotechnology, Konkuk University, Chungju 380-701, Republic of Korea;2. Nokyong Research Centre, Konkuk University, Chungju 380-701, Republic of Korea;1. Programa de Pós-graduação em Patologia, Universidade Federal de Ciências da Saúde de Porto Alegre – UFCSPA, Porto Alegre, Brazil;2. Laboratório de Biofísica Celular e Inflamação, Pontifícia Universidade Católica do Rio Grande do Sul – PUCRS, Porto Alegre, Brazil;3. Centro de Pesquisa Pré-Clínica, Instituto do Cérebro do Rio Grande do Sul – Brain Institute (BraIns), Pontifícia Universidade Católica do Rio Grande do Sul – PUCRS, Porto Alegre, Brazil;4. Laboratório de Neuroproteção e Doenças Neurometabólicas, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul – UFRGS, Porto Alegre, Brazil;5. Laboratório de Proteínas Ligante de Cálcio do Sistema Nervoso Central, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul – UFRGS, Porto Alegre, Brazil |
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| Abstract: | Acute hemodynamic and electrocardiographic effects of fructose-1,6-diphosphate (FDP), an agent that is supposed to restore anaerobic glycolytic flux in the ischemic myocardium, were studied in 40 patients with acute myocardial infarction who were grouped into 4 subsets: subset 1, normal (15 mm Hg or less) pulmonary artery (PA) wedge pressure and normal (35 g-m/m2 or greater) left ventricular (LV) stroke work index; subset 2, elevated (more than 15 mm Hg) PA wedge pressure and normal LV stroke work index; subset 3, normal PA wedge pressure and reduced (less than 35 g-m/m2) LV stroke work index; subset 4, elevated PA wedge pressure and LV stroke work index moderately reduced to a range between 16 and 34 g-m/m2. Patients were randomized into an FDP (250 mg/kg body weight in isotonic saline solution intravenously in 20 minutes) and into a placebo group. Each subset contained 5 FDP- and 5 placebo-treated patients. After basal measurements, hemodynamic measurements were reassessed at 60, 90 and 120 minutes from the infusions, while a standard 12-lead electrocardiogram was recorded in the basal state and 120 minutes after infusion. Nonsignificant hemodynamic change was observed in the placebo subsets, and FDP failed to exert any effect in subsets 1, 2 and 3. A 24% (p less than 0.02) increase in cardiac index occurred 60 minutes after FDP in subset 4. LV stroke work index also increased, while PA wedge pressure remained unchanged.(ABSTRACT TRUNCATED AT 250 WORDS) |
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