代谢综合征与阻塞型睡眠呼吸暂停综合征的相关性分析

目的 初步探讨代谢综合征(MS)与阻塞型睡眠呼吸暂停综合征(OsAs)的相关性.方法 测定并分析82例OSAS患者中43例MS患者(MS组)和39例非MS患者(非MS组)的睡眠呼吸监测指标、MS的组成成分等.结果 (1)MS组的腰围(wc)、体重指数、收缩压(SBP)、inTG、InFBG均高于非MS组(P<0.05或<0.01),高密度脂蛋白胆固醇(HDL-C)低于非MS组(P<0.05).(2)MS组的睡眠呼吸暂停低通气指数(AHI)高于非MS组,最低脉氧饱和度(LSpO2)低于非MS组分别为(43.95±19.18)次/h比(10.58±3.52)次/h、0.67±0.15比0.82±0.07,P<0.01].(3)3个代谢异常组分时,AHI高于0～2个代谢异常组分、LSpO2低于0～2个代谢异常组分(P<0.01);代谢异常组分数进一步增加到4～5个时,AHI进一步增高、LSpO2进一步降低(P<0.05).(4)AHI与InFBG、WC、SBP呈正相关(P<0.01),与HDL-C呈负相关(P<0.01).(5)LSpO2与InFBG、WC、SBP呈负相关(P<0.01),与HDL-C呈正相关(P<0.05).结论 MS和OSAS关系密切.

Study on the correlation between metabolism syndrome and obstructive sleep apnea syndrome

Objective To explore the correlation between metabolism syndrome (MS) and obstructive sleep apnea syndrome (OSAS). Methods Forty-three MS subjects (MS group) and 39 non-MS subjects (non-MS group) were involved in this study. Polysomnography parameters such as apnea hypopnea index (AHI),the lowest pulse oxygen saturation (LSpO2),MS-associated parameters such as lipid,fasting blood ghcose (FBG), blood pressure, and some body indexes such as body mass index (BMI)and waist circumference(WC)wcre measured in all cases. Results (1) WC, BMI, SBP, InTG and InFBG were higher in MS group than those in non-MS group (P < 0.05 or < 0.01), HDL-C was lower in MS group than that in non-MS group (P < 0.05). (2)AHI in MS group was significantly higher than that in non-MS group,while LSpO2 in MS group was significantly lower than that in non-MS group (43.95±19.18) times/h vs (10.58±3.52) times/h, 0.67±0.15 vs 0.82±0.07, respectively, P < 0.01)]. (3)AIR increased and LSpO2 decreased obviously in 3 kinds of abnormal metabolic ingredients group than that in 0-2 kinds of abnormal metabolic ingredients group (P< 0.01). Moreover, AHI further increased and LSpO2 decreased obviously in 4-5 kinds of abnormal metabolic ingredients group than that in 3 kinds of abnormal metabolic ingredients group (P <0.05).(4) AHI was positively correlated with InFBG, WC, SBP and negatively correlated with HDL-C (P < 0.01). (5) LSpO2 was negatively correlated with InFBG, WC, SBP (P < 0.01) and positively correlated with HDL-C(P< 0.05). Conclusion There is close relationship between MS and OSAS.