奥美拉唑与法莫替丁用于三联短程根除幽门螺杆菌的疗效比较

目的　对幽门螺杆菌 (HP)阳性消化性溃疡的患者进行奥美拉唑或法莫替丁加阿莫西林、甲硝唑的三联治疗对比 ,探讨较理想的根除 HP的治疗方案。方法　将 81例经胃镜证实 HP阳性消化性溃疡患者随机分成二组 ,治疗组应用奥美拉唑 2 0 m g,阿莫西林 10 0 0 mg,甲硝唑 4 0 0 mg,每日 2次 ,疗程 1周 ;对照组用法莫替丁 2 0mg,每日 2次 ,阿莫西林和甲硝唑剂量和用法与治疗组相同 ,疗程结束 1月后进行胃镜检查和 HP根除的评估 ;半年后对溃疡痊愈患者再进行胃镜检查 ;观察其溃疡复发率。结果　治疗组溃疡治愈率及总有效率分别为 92 .7%和10 0 % ;对照组分别为 90 .2 %和 95 .0 % ,两组比较 ,差异无显著性 (P>0 .0 5 )。治疗组 HP根除率为 92 .7% ,高于对照组 75 .0 % ,差异有显著性 (P<0 .0 5 )。半年后溃疡复发率治疗组为 7.9% ,较对照组 33.3%明显低差异有显著性(P<0 .0 1)。结论　奥美拉唑三联疗法在使 HP阳性消化性溃疡愈合的同时 ,又具有 HP根除率高、溃疡复发率低等优点 ,是治疗 HP阳性消化性溃疡较为理想的方案

Comparisons of omeprazol and famotdine in one-week triple-therapy to eradicate helicobacter pylori

Objective To study the effect of omeprazol of famotidine plus amoxycillin and metronidazole on eradicate helicobacter pylori(HP)in patients with peptic ulcer,and seek an ideal therapy regimen.Methods The 81 peptic ulcer patients infected with HP were divided randomly into two groups.The therapy group were administrated omeprazole 20 mg,amoxycillin 1000 mg and metronidazole 400 mg,twice a day for one week.The regimen for the control group were similar to former,but omeprazole were replaced by famotidine(20 mg,twice a day).After a month of therapy reexamination of gastroscopy and evaluation of HP eradication were carried out.After another six months,all the patients whose ulcer had been cured would be given the third gastroscopy for evaluation the recurrence of ulcer.Results After therapy,the rateo of healing ulcer and the total effective rate were 92.7% and 90.0% respectively.There were not significant difference among them ( P >0.05).The eradication rate in the therapy group was 92.7%,which was higher than that in control group(75.0%)( P <0.05).The ulcer relapse rate after six months in the therapy group was 7.9%,which was distinctly lower than that in control group(33.3%)( P <0.01).Conclusion The regimen of omeprazol based triple therapy is a ideal project for the patients of peptic ulcer infected with HP,which has a higher eradication rate for HP and a lower ulcer relapse rate.