Sclerema neonatorum and joint contractures at birth as a potential complication of chronic in utero hypoxia |
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| Authors: | R A Molteni M R Ames |
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| Affiliation: | 1. Division of Perinatal Medicine, The Johns Hopkins Hospial Baltimore, Maryland, USA;2. the Division of Neonatology at Francis Scott Key Medical Center Baltimore, Maryland, USA.;1. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Str. 6.131, PO Box 85500, 3508GA Utrecht, The Netherlands;2. Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands;1. Department of Otology and Neurotology, CHU Lille, 59000 Lille, France;2. Inserm U1008, Controlled Drug Delivery Systems and Biomaterials, université de Lille 2, CHU de Lille, 59000 Lille, France;1. Pennsylvania Regional Center for Arthritis & Osteoporosis Research, 1200 Broadcasting Road, Suite 200, Wyomissing, PA 19610, USA;2. Mt Sinai School of Medicine, I Gustave Levy Place New York, New York, NY, USA;1. USDA – ARS Red River Valley Agricultural Research Center, 605 Albrecht Blvd. N, Fargo, ND, 58102, USA;2. USDA – ARS Northern Great Plains Research Laboratory, 1701 10thAve SW, Mandan, ND, 58554, USA;3. North Dakota State University Department of Entomology, 1300 Albrecht Blvd., 202 Hultz Hall, Fargo, ND, 58102, USA;1. National Engineering Research Center of Oil and Gas Pipeline Transportation Safety/ MOE Key Laboratory of Petroleum Engineering /Beijing Key Laboratory of Urban Oil and Gas Distribution Technology, China University of Petroleum-Beijing, 102249, Beijing, China;2. Dipartimento di Energia, Politecnico di Milano, Via La Masa 34, 20156, Milano, Italy;3. MINES ParisTech, PSL Research University, CRC, Sophia Antipolis, France;4. Eminent Scholar, Department of Nuclear Engineering, College of Engineering, Kyung Hee University, Republic of Korea;5. Commissioning Operation Company of China, Petroleum Pipeline Engineering, China;6. Pipechina Oil and Gas Pipeline Control Center, 5 Dongtucheng Street, Chaoyang District, Beijing, 100013, China |
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| Abstract: | Three term neonates presented with an unusual combination of skin changes (sclerema) and joint contractures at birth. In each case a prolonged period of fetal hyporeactivity was reported by the mother. Each child demonstrated a number of clinical findings consistent with chronic fetal hypoxia. Each child recovered with normal joint function. We postulate that sclerema neonatorum and joint contractures are another, though poorly recognized sequela of chronic in utero hypoxia and are preceded by a prolonged period of diminished fetal activity. |
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