Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis |
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Authors: | Donn R P,Farhan A,Stevans A,Ramanan A,Ollier W E R,Thomson W British Paediatric Rheumatology Study Group |
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Affiliation: | Arthritis Research Campaign Epidemiology Unit (ARC/EU), Stopford Building, Oxford Road, Manchester M13 9PT, UK. |
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Abstract: | OBJECTIVE: To investigate the involvement of neuroendocrine candidate genes in the aetiopathogenesis of juvenile idiopathic arthritis (JIA). METHODS: Single-nucleotide polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls. RESULTS: None of the polymorphisms investigated showed any statistically significant associations with JIA. CONCLUSIONS: The lack of association with polymorphisms of these neuroendocrine genes suggests that they are not involved in susceptibility to JIA. |
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