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| 银杏苦内酯B对大鼠任意皮瓣血供的影响 | |
| 引用本文： | 付妍婕,徐启飞,马云霞,张致峰,邢新,熊明根. 银杏苦内酯B对大鼠任意皮瓣血供的影响[J]. 第二军医大学学报, 2001, 22(7): 675-676 |
| 作者姓名： | 付妍婕 徐启飞 马云霞 张致峰 邢新 熊明根 |
| 作者单位： | 1. 第二军医大学长海医院整形外科, 2. 海军杭州疗养院整形外科 3. 第二军医大学长海医院核医学科 4. 第一军医大学珠江医院整形外科 |
| 摘 要： | 目的：通过对皮瓣局部放射性核素显像，观察血小板活化因子拮抗剂BN52021（银杏苦内酯B）对大鼠任意皮瓣各区段血容量的影响。方法：使用BN52021对皮瓣局部进行处理，分别于术后3、6、9h，采用^99mTc体内标记红细胞的方法对皮瓣局部进行显像、绘制感兴趣区（ROI）并计算各段皮瓣的摄取比（UR)，分别与对照组进行比较。结果：使用BN52021处理皮瓣局部，可使皮瓣中、末段的UR明显增加（P＜0．01）。结论：BN52021可以减轻皮瓣局部的炎症反应，减轻血流阻力，改善皮瓣血供。 |
| 关 键 词： | 外科皮瓣 拮抗剂和抑制剂 血小板活化因子 放射性核素显像 ^99mTc 移植 |
| 文章编号： | 0258-879(2001)07-0675-02 |
| 修稿时间： | 2000-11-03 |
The role of BN52021 in the hemodynamics in rat random skin flap |
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| FU Yan Jie ,XU Qi Fei ,MA Yun Xia ,ZHANG Zhi Feng ,XING Xin ,XIONG Ming Gen. The role of BN52021 in the hemodynamics in rat random skin flap[J]. Former Academic Journal of Second Military Medical University, 2001, 22(7): 675-676 | |
| Authors: | FU Yan Jie XU Qi Fei MA Yun Xia ZHANG Zhi Feng XING Xin XIONG Ming Gen |
| Affiliation: | FU Yan Jie 1,XU Qi Fei 2,MA Yun Xia 2,ZHANG Zhi Feng 3,XING Xin 1,XIONG Ming Gen 4 |
| Abstract: | Objective: To evaluate the effect of platelet activating factor(PAF) antagonism on the blood content in the random survival flap. Methods: A lipophilic PAF receptor antagonist BN52021 was administered to treat flaps through a local subcutaneous injection route 30 min prior to transplantation. The flaps were imaged in situ by a gamma camera. Results: The PAF receptor antagonist significantly augmented the accumulation of radioactivity of middle and end part within treated flaps( P <0.01). Conclusion: The specific platelet activating factor receptor antagonist BN52021 is able to diminish the accumulation of acute inflammatory cells directly or indirectly, and is beneficial to the hemodynamic balance of the total flap. [ |
| Keywords: | surgical flaps antagonists and inhibitors platelet activating factor radionuclide imaging 99m Tc |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |