| 14—3—3蛋白 |
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| 引用本文： | 潘伟男（综述） 陈临溪（审校）. 14—3—3蛋白[J]. 中华医学研究杂志, 2006, 6(10): 1103-1106,F0003 |
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| 作者姓名： | 潘伟男（综述） 陈临溪（审校） |
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| 作者单位： | 南华大学药物药理研究所,湖南衡阳421001 |
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| 摘 要： | 14-3-3是一个在真核生物中广泛表达的酸性蛋白家族，主要以同源／异源二聚体形式存在，通过磷酸化丝／苏氨酸作用与靶蛋白或靶蛋白的两个结构域结合。七种不同亚型的高度保守的14-3-3蛋白与人类细胞中多种不同的信号通路有着密切的关系。14-3-3通过调节靶蛋白间的相互作用在MAPK级联放大效应等信号转导途径中发挥调控作用。
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| 关 键 词： | 14—3—3 二聚体 蛋白磷酸化 蛋白质相互作用 信号转导 |
| 文章编号： | 1680-6115（2006）10-1103-04 |
| 收稿时间： | 2006-07-04 |
14 - 3 - 3 proteins |
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| PAN Wei - nan, CHEN Lin - xi ,et al.. 14 - 3 - 3 proteins[J]. JOurnal of Chinese Medicine Research, 2006, 6(10): 1103-1106,F0003 |
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| Authors: | PAN Wei - nan CHEN Lin - xi et al. |
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| Affiliation: | PAN Wei - nan, CHEN Lin - xi , et al . |
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| Abstract: | The 14 - 3 - 3 proteins are a family of abundant, widely expressed, acidic polypeptides in all eukaryocytic cells, which act mainly as either homodimers or heterodimers. The 14- 3 - 3 proteins interact with targeting proteins or two different domains in one targeting protein by phosphoserin but highly conserved 14 - 3 - 3 proteins are involved in diverse signaling e/phosphothreonine motifs. Seven different, pathways in human cells. 14 - 3 - 3 plays a role in controlling interaction with targeting proteins through the MAPK signaling cascade etc. cell signal transduction pathways. |
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| Keywords: | 14 - 3 - 3 dimer targeting proteins phosphorylation protein - protein interaction signal transduction |
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