左氧氟沙星静脉输注给药在Beagle犬体内的药物动力学

目的研究静脉注射左氧氟沙星（Levofloxacin，LVFX）在Beagle犬体内的药动学特性。方法4只Beagle犬静脉注射LVFX，给药剂量25mg·kg^-1，以输液泵调整滴速，60min输注完毕。应用高效液相色谱法测定LVFX血药浓度，应用3P97程序，计算LVFX药动学参数。结果给药后LVFX体内过程符合二房室模型，主要药动学参数：消除半衰期（t1/2β）为（8．23±0．65）h，中央室分布容积（Vc）为（7．47±3．13）L，药时曲线下面积（AUC）N（247．00±14．10）mg·h·L^-1，药物峰浓度（Cmax）为（30．05±1．75）mg·L^-1。结论本研究结果显示，LVFX在Beagle犬体内的药动学特性与在健康人体内的研究结果相近。

Pharmacokinetics of Levofloxacin in Beagle Dogs with Intravenous Infusion

Aim To study the pharmacokinetics of Levofloxacin （LVFX） in beagle dogs. Methods Four Beagle dogs were administered with a single dose of LVFX （25mg· kg^-1） by intravenous infusion（ for 60min）. Plasma concentration of LVFX in Beagle dogs was determined by RP-HPLC. The pharmacokinetic parameters of LVFX in Beagle dogs were calculated by 3P97 software. Results The plasma concentration-time curve of LVFX in Beagle dogs confomed to a two-compartment model. Pharmacokintic parameters were t1/2β （ 8.23 ± 0.65 ） h, Vo （7.47 ± 3.13 ） L, AUC （247.00 ± 14.10） mg· h· L^- 1, Cmax （ 30.05 ± 1.75 ） mg· L^ -1, respectively. Conclusion Pharmacokinetic characteristics of LVFX in Beagle dogs were similar with those of humans.