| 胰高糖素样肽1类似物治疗糖尿病的研究进展 |
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| 引用本文： | 蒋飞霞. 胰高糖素样肽1类似物治疗糖尿病的研究进展[J]. 医学综述, 2011, 17(14) |
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| 作者姓名： | 蒋飞霞 |
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| 作者单位： | 广西医科大学第一附属医院代谢糖尿病中心,南宁,530021 |
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| 摘 要： | 胰高糖素样肽1(GLP-1)是一种肠肽类激素,GLP-1不仅可促进胰岛素合成和分泌、抑制B细胞凋亡、促进B细胞增殖、抑制胰高糖素分泌;还可降低食欲,延缓胃排空;GLP-1对心血管功能产生有益作用。人GLP-1类似物适用于二甲双胍、磺脲类和(或)胰岛素增敏剂控制血糖仍不满意的2型糖尿病患者。在1型糖尿病中,GLP-1对空腹血糖的作用,取决于患者血糖、胰升糖素水平及残存胰岛B细胞功能。GLP-1能改善餐后血糖的波动,根据患者残存B细胞功能的多少,其作用机制可能有差别。
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| 关 键 词： | 胰高糖素样肽1类似物 糖尿病 治疗 |
The Progress of Glucagon-like Peptide-1 Analogue in Treatment of Diabetes Mellitus |
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| JIANG Fei-xia. The Progress of Glucagon-like Peptide-1 Analogue in Treatment of Diabetes Mellitus[J]. Medical Recapitulate, 2011, 17(14) |
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| Authors: | JIANG Fei-xia |
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| Affiliation: | JIANG Fei-xia,WANG Nai-Zun.(Center for Metabolism and Diabetes,the First Affiliated Hospital,Guangxi Medical University,Nanning 530021,China) |
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| Abstract: | Glucagon-like peptide-1(GLP-1),as a gut hormone,in addition to stimulating insulin secretion and promoting pancreatic B-cell mass,GLP-1 suppresses glucagon secretion,delays gastric emptying and inhibits food intake.Their glucose-dependent mechanism limits the risk for hypoglycemia.GLP-1 improved cardiac function in humans.GLP-1 analogue is used in type 2 diabetic patients who are not sufficiently controlled by metformin and sulfonylurea.GLP-1 is able to lower fasting glycemia also in type Ⅰ diabetic patients,mainly by reducing glucagon concentrations and by remnant pancreatic B-cell secretion.The mechanism of lowering postprandial glycemia in type Ⅰ diabetic patients is different according to remnant pancreatic B-cell mass. |
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| Keywords: | Glucagon-like peptide-1 analogue Diabetes Treatment |
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