| 276例手术切除肺腺癌亚型与EGFR/ALK基因状态 |
| |
| 引用本文： | 庄武,钟礼花,陈芳芳,陈燕坪,黄韵坚,黄章洲,卢建平,王晓江,师怡,林贤东,许春伟,陈刚. 276例手术切除肺腺癌亚型与EGFR/ALK基因状态[J]. 国际病理科学与临床杂志, 2017, 37(4). DOI: 10.3978/j.issn.2095-6959.2017.04.002 |
| |
| 作者姓名： | 庄武 钟礼花 陈芳芳 陈燕坪 黄韵坚 黄章洲 卢建平 王晓江 师怡 林贤东 许春伟 陈刚 |
| |
| 作者单位： | 1. 福建医科大学附属福建省肿瘤医院胸部肿瘤内科,福州,350014;2. 福建医科大学附属福建省肿瘤医院病理科,福州,350014 |
| |
| 基金项目： | 国家临床重点专科建设项目，福建省科技厅引导性项目(2015Y0011;2016Y0019).This work was supported by National Clinical Key Specialty Construction Program，Leading Project Foundation of Science Department of Fujian Province，China |
| |
| 摘 要： | 目的:探讨手术切除肺腺癌各亚型EGFR和ALK基因状态分布.方法:应用ARMS方法检测手术切除肺腺癌石蜡组织中EGFR基因突变和ALK融合基因情况.结果:276例肺腺癌手术样本中,EGFR基因突变率为54.71％(151/276),其中19del为28.99％(80/276),L858R为23.19％(64/276),20-ins为0.72％(2/276),L861Q为0.72％(2/276),G719X为1.09％(3/276),S768I为0.36％(1/276)和T790M为0.72％(2/276),其中包含G719X+S768I,19del+T790M,L858R+T790M各1例,ALK基因融合阳性率为5.80％(12/207),在肺腺癌各亚型中EGFR基因突变附壁状腺癌,腺泡状腺癌,乳头状腺癌,实体状腺癌和浸润性黏液腺癌之间差异有统计学意义(P＜0.001,P=0.009,P=0.023,P＜0.001和P=0.030),与其他类型之间差异均无统计学意义(P＞0.05);在肺腺癌各亚型中ALK融合基因突变各亚型之间差异均无统计学意义(P＞0.05).结论:肺腺癌组织学亚型与EGFR基因突变有关,附壁状腺癌、腺泡状腺癌和乳头状腺癌出现EGFR基因突变比其他亚型更加明显.
|
| 关 键 词： | 肺腺癌 手术 EGFR基因 ALK基因 突变率 |
EGFR/ALK gene status of 276 cases of surgically resected lung adenocarcinomas |
| |
| ZHUANG Wu,ZHONG Lihua,CHEN Fangfang,CHEN Yanping,HUANG Yunjian,HUANG Zhangzhou,LU Jianping,WANG Xiaojiang,SHI Yi,LIN Xiandong,XU Chunwei,CHEN Gang. EGFR/ALK gene status of 276 cases of surgically resected lung adenocarcinomas[J]. Journal of International Pathology and Clinical Medicine, 2017, 37(4). DOI: 10.3978/j.issn.2095-6959.2017.04.002 |
| |
| Authors: | ZHUANG Wu ZHONG Lihua CHEN Fangfang CHEN Yanping HUANG Yunjian HUANG Zhangzhou LU Jianping WANG Xiaojiang SHI Yi LIN Xiandong XU Chunwei CHEN Gang |
| |
| Abstract: | Objective:To investigate the mutations of EGFR gene and ALK fusion gene in surgically resected lung adenocarcinomas.Methods:ARMS method was used to detect the tissues in 276 patients of surgically resected lung adenocarcinomas with paraffin tissue EGFR gene mutation and ALK fusion gene.Results:The total mutation rate in 276 patients of surgically resected lung adenocarcinomas was 54.71％ (151/276).EGFR gene mutation rate were found in 19del (28.99％,80/276),L858R (23.19％,64/276),20-ins (0.72％,2/276),L861Q(0.72％,2/276),G719X (1.09％,3/276),S768I (0.36％,1/276) and T790M (0.72％,2/276) in surgically resected lung adenocarcinomas,including one case of G719X+S768I,19del+T790M,L858R+T790M,respectively.The total fusion positive rate in 207 patients of surgically resected lung adenocarcinomas was 5.80％ (12/207).There were statistically significant (P＜0.001,P＜0.001,P=0.023,P＜0.001 and P=0.030) in each subtype of lung adenocarcinoma ofEGFR gene mutation,including lepidic predominant adenocarcinoma,acinar predominant adenocarcinoma,papillary predominant adenocarcinoma,solid predominant adenocarcinoma and invasive mucous adenocarcinoma,and there were not statistically significant (P＞0.05) among other types.There were not statistically significant (P＞0.05) among each types of lung adenocarcinoma of ALK fusion gene.Conclusion:Histologic subtyping was found to be associated with EGFR mutations.The EGFR mutation frequency of lepidic predominant,acinar predominant and papillary predominant subtypes was found to be more pronounced than that of other subtypes. |
| |
| Keywords: | lung adenocarcinoma surgery EGFR gene ALK gene mutation rate |
| 本文献已被 万方数据 等数据库收录！ |
|
