| SIRT3与胰岛素抵抗 |
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| 引用本文： | 冯静,魏亚聪,刘超,宋光耀.SIRT3与胰岛素抵抗[J].国际内分泌代谢杂志,2017,37(5). |
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| 作者姓名： | 冯静 魏亚聪 刘超 宋光耀 |
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| 作者单位： | 河北省人民医院内分泌科,石家庄,050051 |
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| 摘 要： | 沉默信息调节因子(SIRT)3是哺乳动物类NAD+依赖性组蛋白去乙酰化酶家族中的一员.研究表明,SIRT3可以改善胰岛素抵抗、增加胰岛素敏感性.其通过保护胰岛β细胞、促进骨骼肌葡萄糖摄取、调节骨骼肌代谢、减轻氧化应激、抵抗高糖诱导的细胞毒性等途径发挥作用.SIRT3为治疗2型糖尿病、肥胖、线粒体功能障碍等疾病带来了新的研究方向.
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| 关 键 词： | SIRT3 胰岛素抵抗 糖尿病 线粒体 |
SIRT3 and insulin resistance |
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| Feng Jing,Wei Yacong,Liu Chao,Song Guangyao.SIRT3 and insulin resistance[J].International JOurnal of Endocrinology and Metabolism,2017,37(5). |
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| Authors: | Feng Jing Wei Yacong Liu Chao Song Guangyao |
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| Abstract: | Sirtuin 3 (SIRT3) is a member of Sirtuins family and a kind of NAD+-dependent deacetylase.Studies show that SIRT3 plays an important role in improving insulin resistance, increasing insulin sensitivity.SIRT3 can protect pancreatic β cells, facilitate glucose uptake, regulate metabolic flexibility in skeletal muscle, reduce oxidative stress and protects cells from high glucose-induced cytotoxicity.SIRT3could be a promising target for treating diabetes, obesity and some mitochondrial dysfunctional diseases. |
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| Keywords: | SIRT3 Insulin resistance Diabetes mellitus Mitochondria |
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