痤疮与胰岛素抵抗相关性的研究进展

痤疮是好发于青春期的毛囊皮脂腺慢性炎症性疾病，激素是痤疮发生的最重要内源性因素。近年来发现，除雄激素外，胰岛素抵抗及其诱导的胰岛素和胰岛素样生长因子1水平异常也与痤疮密切相关，胰岛素与胰岛素样生长因子1通过间接刺激雄激素分泌、直接诱导角质形成细胞增殖和皮脂腺细胞脂质分泌以及炎症过程参与痤疮发生。此外，痤疮作为某些系统性疾病或综合征如多囊卵巢综合征、高雄激素血症?胰岛素抵抗?黑棘皮病综合征的重要特征以及饮食、吸烟、肿瘤与痤疮的相关性也为胰岛素抵抗在痤疮发生中的潜在作用提供了依据。

Relationship between acne and insulin resistance

Acne is a chronic inflammatory disease of the pilosebaceous unit with predilection for adolescents. Hormones are the most important endogenous factor for the occurrence of acne. Recently, it has been found that besides androgen, insulin resistance and abnormal levels of insulin and insulin?like growth factor?1(IGF?1)induced by insulin resistance were closely associated with acne. Concretely speaking, insulin and IGF?1 may participate in the occurrence of acne by indirectly stimulating androgen secretion and directly inducing keratinocyte proliferation, sebaceous lipogenesis and inflammatory responses. In addition, the fact that acne is an important clinical characteristic of some systemic diseases or syndromes, such as polycystic ovary syndrome(PCOS)and hyperandrogenism?insulin resistance?acanthosis nigricans (HAIR?AN)syndrome, and associations of acne with diet, smoking and tumors, all provide evidence for the potential role of insulin resistance in the occurrence of acne.