| 短链脂肪酸在2型糖尿病发病机制中的作用 |
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| 引用本文： | 王雪姣,丁晓颖,彭永德. 短链脂肪酸在2型糖尿病发病机制中的作用[J]. 国际内分泌代谢杂志, 2017, 37(4). DOI: 10.3760/cma.j.issn.1673-4157.2017.04.014 |
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| 作者姓名： | 王雪姣 丁晓颖 彭永德 |
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| 作者单位： | 200080,上海交通大学附属第一人民医院内分泌代谢科 |
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| 基金项目： | National Natural Science Foundation of China，Key Projects of Shanghai Municipal Health Bureau Research Fund，Shanghai Jiaotong University Research Funding on Medical and Engineering Interdisciplinary Projects，Wang Kuancheng Prize Fund for Medicine;Shanghai Jiaotong University School of Medicine，Project for Science and Technology Development of Shanghai Songjiang District，Songjiang District Health Bureau of Climbing Medical Program，Shanghai Shen Kang Hospital Development Center for Chronic Disease Prevention and Control Project (SHDC12015304)国家自然科学基金资助项目，上海市卫计委重点项目，上海交通大学医工交叉项目，上海交通大学医学院王宽诚医学奖励基金项目，上海松江科委项目，上海松江卫计委攀登医学合作项目，上海申康医院发展中心临床科技创新项目 |
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| 摘 要： | 短链脂肪酸(SCFA)是由肠道菌群发酵膳食纤维产生的代谢产物,饮食结构变化通过改变肠道菌群结构与功能,影响SCFA的产生.近来研究发现,SCFA通过调节胃肠道激素分泌、胰岛素敏感性及糖、脂代谢,参与了2型糖尿病的发生、发展.对SCFA的深入研究,为阐明2型糖尿病发病机制及其预防和治疗提供了新的思路和靶点.
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| 关 键 词： | 短链脂肪酸 肠道菌群 肥胖 代谢综合征 2型糖尿病 |
The role of short chain fatty acids in the pathogenesis of type 2 diabetes mellitus |
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| Wang Xuejiao,Ding Xiaoying,Peng Yongde. The role of short chain fatty acids in the pathogenesis of type 2 diabetes mellitus[J]. International JOurnal of Endocrinology and Metabolism, 2017, 37(4). DOI: 10.3760/cma.j.issn.1673-4157.2017.04.014 |
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| Authors: | Wang Xuejiao Ding Xiaoying Peng Yongde |
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| Abstract: | Short chain fatty acids (SCFA) are metabolic products of the gut microbiota fermentation of dietary fiber,and are influenced by the structure and function of gut microbiota with the change of diet.Recent studies have indicated that SCFA may play an important role in the pathogenesis of type 2 diabetes mellitus,which is involved in the regulation of secretion of gut hormones,insulin sensitivity,glucose and lipid metabolism and so on.Further researches related to SCFA may provide a new measure and target to clarify the pathogenesis of type 2 diabetes mellitus as well as to prevent and treat it. |
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| Keywords: | Short chain fatty acids Gut microbiota Obesity Metabolic syndrome Type 2 diabetes mellitus |
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