眼动脉经颅多普勒对颅内静脉窦血栓患者颅内压变化的预测研究

目的探讨眼动脉经颅多普勒(TCD)对颅内静脉窦血栓形成(CVST)患者颅内压变化的预测研究。方法临床确诊为CVST,且伴有视觉障碍和双眼视乳头水肿患者。分别于治疗前、治疗后5~15 d和治疗后30~45 d行眼动脉TCD后立即行腰穿记录颅内压值(ICP)。通过眼动脉颅内和颅外段搏动指数(PI),计算搏动指数变化率(△PI),并进行相应时段ICP与△PI之间相关性分析。结果在治疗前、治疗后5~15 d和治疗后30~45 d相应时段ICP与△PI之间均有相关性,P值均为0.000。结论眼动脉颅内和颅外段搏动指数变化率可作为预测CVST患者颅内压变化的一种无创指标。

Value of ophthalmic artery transcranial Doppler in predicting the change in intracranial pressure in patients with intracranial venous sinus thrombosis

Objective To investigate the value of ophthalmic artery transcranial Doppler (TCD) in predicting the change in intracranial pressure (ICP) in patients with intracranial venous sinus thrombosis (CVST).Methods The patients who were diagnosed with CVST and had visual impairment and binocular optic disc edema were enrolled.Ophthalmic artery TCD was performed before treatment and at 5-15 and 30-45 days after treatment,and lumbar puncture was performed immediately after ophthalmic artery TCD to record ICP.The pulsatility index (PI) of the intracranial and extracranial sections of the ophthalmic artery was used to calculate the rate of change of PI (△PI),and the correlation between ICP and △PI within the same period of time was analyzed.Results There was a strong correlation between ICP and △PI before treatment and at 5-15 and 30-45 days after treatment (P =0.000).Conclusions △PI of intracranial and extracranial sections of the ophthalmic artery can be used as a noninvasive index for predicting the change in ICP in patients with CVST.