气管多形性腺瘤1例并文献复习

目的:探讨气管多形性腺瘤的临床病理特征、诊断和鉴别诊断.方法:分析l例气管多形性腺瘤的临床病理资料、病理结果,并复习文献.结果:肿物大小2.5cm×1.5cm×1.0 cm,表面光滑,不规则结节状,切面灰白,半透明,质软韧,无明显出血和坏死.光镜下由上皮组织和间质组织两种成分构成,上皮细胞呈巢状、条索状及梁状漂浮在软骨黏液样间质背景中,局灶可见到腺样结构,细胞胞浆嗜酸性,无明显细胞异型性和核分裂象.免疫组织化学检查肌上皮细胞CK,S-100和P63阳性表达.腺上皮CK,CK7和CK19标记阳性.结论:气管多形性腺瘤少见,诊断气管内肿瘤时要考虑到这个鉴别诊断,以免漏诊或误诊.未来需要研究更多气管多形性腺瘤病例以进一步完善其临床进程、生物学行为和预后.

Tracheal pleomorphic adenoma: report of one case and review of the literature

Objective:To explore the clinicopathological features,diagnosis and differential diagnosis of tracheal pleomorphic adenoma.Methods:We observed the clinical data,histopathology, immunohistochemistry of a case of tracheal pleomorphic adenoma,and reviewed some relevant literatures.Results:The tumor was smoothing appeared as the surface,irregular nodular,measuring 2.5 cm × 1.5 cm × 1.0 cm in size.The tumor was gray-white on cut surface,soft to rubbery translucent,and couldn't be observed obviously bleeding and necrosis.Under light microscope,the mass was composed of epithelial and myoepithelial cells.The epithelial ceils were nest-shaped,cord-like and beam in the chondromyxoid stroma.The epithelial cells had normochromic nudeus with eosinophilic cytoplasms and had glandular distribution in some parts.There was no definitive cellular pleomorphism and mitotic figures.Immunohistochemically,cytokeratin,S-1 00 protein,and p63 of myoepithelial cells expressed positively.Cytokeratin,cytokeratin 19 and cytokeratin 7 of epithelial cells were positive.Conclusion:Pleomorphic adenoma of the trachea should be included in the differential diagnosis of tracheal tumors,so as not to misdiagnosis,although the occurrence is very rare.Future studies with additional cases are needed in order to define the clinical course,biologic behavior and prognosis ofpleomorphic adenoma of the trachea.