| 脂蛋白脂酶基因多态性与动脉粥样硬化 |
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| 引用本文： | 陈歆,徐运.脂蛋白脂酶基因多态性与动脉粥样硬化[J].国际脑血管病杂志,2017,25(2). |
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| 作者姓名： | 陈歆 徐运 |
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| 作者单位： | 210008,南京大学医学院附属鼓楼医院神经内科 |
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| 基金项目： | 国家自然科学基金，江苏省科技项目，科技部专项课题(2016YFC1300500)National Natural Science Foundation of China，Science and Technology Project of Jiangsu Province，Special Topics of the Ministry of Science and Technology |
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| 摘 要： | 脂蛋白脂酶(lipoprotein lipase,LPL)是富含三酰甘油的脂蛋白的三酰甘油核心水解的限速酶,其不仅会影响脂蛋白水平,还在动脉粥样硬化的形成和发展中起着重要作用.LPL基因多态性会影响酶活性,从而具有促动脉粥样硬化或抗动脉粥样硬化的作用.文章对LPL基因多态性与动脉粥样硬化的关系进行了综述.
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| 关 键 词： | 动脉粥样硬化 脂蛋白脂酶 多态现象 遗传学 危险因素 |
Lipoprotein lipase gene polymorphisms and atherosclerosis |
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| Chen Xin,Xu Yun.Lipoprotein lipase gene polymorphisms and atherosclerosis[J].International Journal of Cerebrovascular Diseases,2017,25(2). |
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| Authors: | Chen Xin Xu Yun |
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| Abstract: | Lipoprotein lipase (LPL) is the rate-limiting enzyme for the hydrolysis of the triglyceride core of circulating triglyceride-rich lipoproteins.LPL can not only affect the lipoprotein level,but also play an important role in the development of atherosclerosis.LPL gene polymorphisms may affect LPL activity,and therefore have both pro-and anti-atherogenic effects.This article reviews the relationship between LPL gene polymorphism and atherosclerosis. |
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| Keywords: | Atherosclerosis Lipoprotein Lipase Polymorphism Genetic Risk Factors |
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