白细胞介素33/转硫酶同系物2信号通路与皮肤相关性疾病的研究进展

白细胞介素33/转硫酶同系物2信号通路是一条促炎症通路，通过增加T淋巴细胞介导的炎症反应刺激Th2细胞因子的分泌，促进肥大细胞和嗜酸性粒细胞脱颗粒，及诱导Th2细胞和中性粒细胞趋化，在银屑病、白癜风、特应性皮炎和鳞状细胞癌等多种皮肤炎症性疾病的免疫反应和肿瘤的免疫应答中发挥作用。研究表明，转硫酶同系物2基因存在单核苷酸多态性及编码变异，因此，白细胞介素33/转硫酶同系物2通路在疾病的发病机制中也表现了一定的遗传背景。转硫酶同系物2基因多态性可能提高了患者的患病风险。免疫组化可以指导治疗方案的选择和预后的判断，而白细胞介素33和（或）转硫酶同系物2水平的降低则有利于炎症性疾病的治疗。

Interleukin-33/sulfurtransferase homolog 2 signaling pathway and related skin diseases

Interleukin?33 (IL?33)/sulfurtransferase homolog 2 (ST2) signaling pathway, a pro?inflammatory pathway, plays an important role in immune reactions in multiple inflammatory skin diseases (such as psoriasis, vitiligo and atopic dermatitis) and tumors (such as squamous cell carcinoma) by enhancing T lymphocyte?mediated inflammatory reactions, stimulating secretion of T helper type 2(Th2) cytokines, promoting degranulation of mast cells and eosinophils, and inducing chemotaxis of Th2 cells and neutrophils. Studies have indicated single nucleotide polymorphisms(SNPs)and encoding variability of the ST2 gene, which may contribute to the genetic background of the IL?33/ST2 signaling pathway in the pathogenesis of diseases. ST2 gene polymorphisms may increase the risk of diseases in patients. Immunohistochemical study may be used to guide the choice of treatment protocols and judgment of prognoses. Moreover, the decrease in IL?33 and/or ST2 levels is beneficial to the treatment of inflammatory diseases.