痤疮相关基因多态性的研究进展

痤疮是一种可能与多基因遗传有关的累及毛囊皮脂腺的炎症性皮肤病,发病机制复杂,目前尚未完全阐明.已有研究表明,某些基因的单核苷酸多态性可能与痤疮易感性相关,如SELL基因、RETN基因、DDB2基因、MYC基因、转化生长因子通路相关基因、胰岛素样生长因子1基因等.从炎症相关基因多态性、推激素受体相关基因多态性、转化生长因子β通路相关基因多态性及胰岛素受体相关基因多态性4个方面,探讨痤疮相关基因多态性的研究进展.深入探索痤疮相关基因多态性对基因靶向药物的研发有重要意义.

Acne-associated gene polymorphisms

Acne,a kind of inflammatory skin disease involving pilosebaceous units,is likely associated with polygenic inheritance.Its pathogenesis is very complex,and remains unclear currently.Several studies have indicated that single nucleotide polymorphisms (SNPs)in some genes may be related to the susceptibility to acne,such as the L-selectin gene,resistin gene,damage-specific DNA binding protein 2 gene,MYC gene,linked to transforming growth factor pathway-related genes,insulin-like growth factor-1 gene,and so on.This review summarizes research progress in acne-associated gene polymorphisms in 4 aspects,including inflammation-related gene SNPs,androgen receptor-related gene SNPs,transforming growth factor-β pathway-related gene SNPs and insulin-like growth factor-related gene SNPs.To further understand acne-associated gene polymorphisms is of great significance for the research and development of gene-targeting drugs.