DJ-1基因多态性与帕金森病易感性的Meta分析

目的评价DJ-1基因多态性与帕金森病(PD)易感性的关系。方法检索知网、万方、Web of Science、Pub Med、EMBASE和Cochrane数据库,检索时间为2001年01月01日至2017年01月01日。确定文献纳入排除标准,并采用Newcastle-Ottawa Scale(NOS)进行质量评估,提取高质量文献的有用部分,使用stata12.0软件进行统计分析。结果共纳入12篇文献,收集到2895组病例和2817组对照,Meta分析结果显示,在帕金森病患者中,DJ-1基因g.168_185del缺失突变(OR=1.26,95%CI:1.06~1.50,P0.05)和c.G293A点突变(OR=2.74,95%CI:1.22~6.16,P0.05)均为PD的危险因素。在g.168_185del与PD相关性研究的亚组分析中,发现非中国人群g.168_185del多态性也是PD的危险因素(OR=1.41,95%CI:1.14~1.73,P0.05),但在中国人群中未发现其相关性(OR=0.98,95%CI:0.72~1.34,P0.05)。c.G293A与PD相关性病例对照研究中均为非中国人群,故未进行亚组分析。结论DJ-1基因g.168_185 del缺失突变和c.G293A点突变是PD的易感因素,但本Meta分析未发现DJ-1基因g.168_185 del缺失突变和c.G293A点突变与中国人群PD具有相关性。

Association between DJ-1 gene polymorphisms and susceptibility to Parkinson's disease:a meta-analysis

Objective To investigate the association between DJ-1 gene polymorphisms and susceptibility to Parkinson's disease (PD).Methods CNKI,Wanfang Data,Web of Science,PubMed,EMBASE,and Cochrane Library were searched for articles published from January 1,2001 to January 1,2017.The inclusion and exclusion criteria for articles were determined,and the NewcastleOttawa Scale was used for quality evaluation.Related data were extracted from high-quality articles and the stata12.0 software was used for the statistical analysis.Results Twelve articles were included,with 2895 patients in case group and 2817 healthy controls.The meta-analysis showed that in patients with PD,D J-1 gene g.168_185del deletion mutation [odds ratio (OR) =1.26,95％ confidence interval (CI) 1.06-1.50,P ＜ 0.05) and c.G293A point mutation (OR =2.74,95％ CI 1.22-6.16,P ＜ 0.05) were risk factors for PD.The subgroup analysis of the association between g.168_185del and PD showed that g.168_185del polymorphism was also a risk factor for PD in non-Chinese populations (OR =1.41,95％ CI 1.14-1.73,P ＜0.05),but such association was not observed in the Chinese population (OR =0.98,95％ CI 0.72-1.34,P ＞ 0.05).The case-control study of the association between c.G293A polymorphism and PD was conducted in non-Chinese populations,so a subgroup analysis was not performed.Conclusions D J-1 gene g.168_185del deletion mutation and c.G293A point mutation are risk factors for PD,while this meta-analysis does not find the association between these polymorphisms and PD in the Chinese population.