| ABC转运体介导肿瘤多药耐药机制的研究进展 |
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| 引用本文： | 熊婷,李丽丁. ABC转运体介导肿瘤多药耐药机制的研究进展[J]. 国际病理科学与临床杂志, 2017, 37(1). DOI: 10.3978/j.issn.2095-6959.2017.01.032 |
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| 作者姓名： | 熊婷 李丽丁 |
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| 作者单位： | 南华大学药物药理研究所,湖南衡阳,421001 |
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| 基金项目： | 国家自然科学基金，湖南省自然科学基金，湖南省教育厅创新平台项目，“湖南省分子靶标新药研究协同创新中心”培育项目，南华大学分子靶标新药协同创新中心研究生创新项目，南华大学大学生创新性课题(2016NH049XJXZ).This work was supported by National Natural Science Foundation of China，Natural Science Foundation of Hunan Province，the Open Fund Based on Innovation Platform of Hunan Provincial Education Department，Hunan Provincial Cooperative Innovation Center for Molecular Target New Drug Study，Innovation Program of Graduate Education in Cooperative Innovation Center for Molecular Target New Drug of University of South China，the College Students' Innovative Project of University of South China |
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| 摘 要： | 多药耐药(multidrug resistance,MDR)是导致肿瘤化疗失败的主要原因之一,而过表达三磷酸腺苷结合盒(ATP binding cassette,ABC)转运蛋白是导致MDR产生的主要机制.因此,筛选ABC转运蛋白的抑制剂,在逆转肿瘤MDR提高肿瘤化疗疗效中具有重要的意义.
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| 关 键 词： | 三磷酸腺苷结合盒转运蛋白 肿瘤 多药耐药 |
Research progress of ABC transporter mediated multidrug resistance mechanism |
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| XIONG Ting,LI Liding. Research progress of ABC transporter mediated multidrug resistance mechanism[J]. Journal of International Pathology and Clinical Medicine, 2017, 37(1). DOI: 10.3978/j.issn.2095-6959.2017.01.032 |
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| Authors: | XIONG Ting LI Liding |
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| Abstract: | Multidrug resistance (MDR) is one of the main causes of tumor chemotherapy failure,and the ATP binding cassette (ABC) transporter over-expression is one of the main mechanism of MDR.Therefore,screening ABC transporter proteins inhibitor is one of the effective ways to improve the effect of chemotherapy in reversing the MDR. |
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| Keywords: | ATP binding cassette transporter proteins tumor multidrug resistance (MDR) |
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