胰岛素生长因子受体-2在肝细胞癌预后判断中的临床价值

目的:探讨胰岛素生长因子受体-2(insulin-like growth factor-2 receptor,IGF-2R)在肝细胞癌(hepatocellular carcinoma,HCC)预后判断中的临床价值.方法:采用免疫组织化学染色(IHC)检测人类肝癌组织中IGF-2R的表达,并分析IGF-2R组织水平与HCC患者临床病理特征之间关系.结果:IHC结果显示IGF-2R主要在HCC细胞的胞质和胞膜中表达,与匹配的癌旁正常组织相比,IGF-2R蛋白水平在HCC组织中更高,差异有统计学意义(P＜0.05),并且与肿瘤分化程度正相关(P=0.012).单变量和多变量生存分析显示TNM分期(HR=9.87,95％CI 4.13～17.80,P=0.008)、门脉癌栓(HR=5.21,95％CI 1.38～10.76,P=0.023)和IGF-2R高表达(HR=2.30,95％CI 1.20～5.01,P=0.033)与HCC患者预后不良相关.结论:这些数据表明IGF-2R表达与HCC患者的总体存活负相关,是潜在的HCC新型分子靶标和预后标志物.

Clinical value of IGF-2R in prognosis of hepatocellular carcinoma

Objective:To study the clinical value of insulin-like growth factor-2 receptor (IGF-2R) in the prognosis of hepatocellular carcinoma (HCC).Methods:We examined IGF-2R expression in human HCC tissues by immunohistochemical staining,and investigated the clinical correlation between IGF-2R tissue levels and the clinicopathological characteristics of HCC patients.Results:Immunohistochemistry results revealed that IGF2R was mainly expressed in the cell membrane and plasma of HCC cells.IGF-2R protein levels were significantly higher in HCC tissues when compared with matched non-cancerous tissues,the difference was statistically significant (P＜0.05),and associated with the degree of tumor differentiation (P=0.012).Univariate and multivariate survival analysis revealed that patients with high IGF-2R expression (HR =9.87,95％ CI 4.13-17.80,P=0.008)and advanced TNM stage (HR =5.21,95％ CI 1.38-10.76,P=0.023) and poor prognosis (HR =2.30,95％ CI 1.20-5.01,P=0.033).Conclusion:These data indicate that IGF-2R expression is associated with the overall survival of HCC patients,and may represent a novel molecular target and newprognostic biomarker for HCC.