| 磷脂酰肌醇3激酶/蛋白激酶B/雷帕霉素靶蛋白信号通路在肺部疾病中的研究进展 |
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| 引用本文： | 杨春兰. 磷脂酰肌醇3激酶/蛋白激酶B/雷帕霉素靶蛋白信号通路在肺部疾病中的研究进展[J]. 国际病理科学与临床杂志, 2017, 37(4). DOI: 10.3978/j.issn.2095-6959.2017.04.028 |
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| 作者姓名： | 杨春兰 |
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| 作者单位： | 南华大学附属省老年医院呼吸科/湖南省老年医学研究所呼吸疾病研究室,长沙,410016 |
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| 基金项目： | 国家自然科学基金，湖南省研究生创新性课题(CX2016B496).This work was supported by the National Natural Science Foundation，Innovative Subject of Graduate Students in Hunan Province，China |
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| 摘 要： | 磷脂酰肌醇3激酶/蛋白激酶B/雷帕霉素靶蛋白(phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin,PI3K/Akt/mTOR)是细胞内重要信号通路,在细胞生长、增殖、分化和蛋白合成等过程中起重要作用.肺癌、哮喘、肺动脉高压、肺纤维化、慢性阻塞性肺疾病(chronic pulmonary obstructive disease,CORD)等疾病是呼吸系统常见疾病,其病理机制涉及细胞增殖及凋亡等,与PI3K/Akt/mTOR信号通路关系密切.
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| 关 键 词： | 磷脂酰肌醇3激酶/蛋白激酶B/雷帕霉素靶蛋白信号通路 呼吸系统疾病 病理机制 |
Research progress of phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin signal pathway in pulmonary diseases |
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| YANG Chunlan. Research progress of phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin signal pathway in pulmonary diseases[J]. Journal of International Pathology and Clinical Medicine, 2017, 37(4). DOI: 10.3978/j.issn.2095-6959.2017.04.028 |
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| Authors: | YANG Chunlan |
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| Abstract: | Phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR)signal pathway is an important intracellular signal pathway,playing pivotal role in cell growth,proliferation,differentiation,DNA synthesis.Pulmonary carcinoma,asthma,pulmonary artery hypertension,pulmonary fibrosis,chronic pulmonary obstructive disease (COPD) are common chronic respiratory diseases,and their patho-mechanisms involve cell proliferation and growth,which have intimate relationship with PI3K/Akt/mTOR. |
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| Keywords: | PI3K/Akt/mTOR signal pathway pulmonary disease pathogenesis |
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