白癜风与自身免疫性甲状腺疾病的研究进展

临床流行病学研究发现,白癜风常伴发一些自身免疫性疾病,特别是自身免疫性甲状腺疾病.关于白癜风伴发自身免疫性甲状腺疾病已有许多的病例报道.相对于健康人群,白癜风患者中甲状腺相关抗体水平升高,伴发自身免疫性甲状腺疾病的白癜风患者往往患病年限长,皮损范围较大.白癜风患者体内Th17/Treg失衡,黑素细胞表达的相关蛋白被看作自身抗原,这些抗原有部分也表达于甲状腺组织,这是白癜风伴发自身免疫性甲状腺疾病的免疫基础.白癜风的易感基因位点有些与自身免疫疾病相关,这些位点是白癜风伴发自身免疫性甲状腺疾病的遗传因素.目前发现,-428T FoxD3变异与白癜风发生有密切关系,与抗TPO抗体及抗甲状腺球蛋白抗体升高相关.

Vitiligo and autoimmune thyroid diseases

Clinico-epidemiological studies have found that vitiligo is often complicated by some autoimmune diseases,especially autoimmune thyroid disease.There have been many case reports about vitiligo complicated by autoimmune thyroid disease.Compared with healthy population,levels of thyroid-associated antibodies are elevated in patients with vitiligo,and vitiligo patients with autoimmune thyroid disease usually have long disease duration and widely-distributed skin lesions.The Th17/Treg imbalance is observed in patients with vitiligo.Some proteins expressed by melanocytes are regarded as autoantigens,and some of these antigens can also be expressed in the thyroid tissue.These are immune basis for the coexistence of vitiligo and autoimmune thyroid disease.Some of vitiligo susceptibility gene loci are associated with autoimmune diseases,which are genetic basis of the coexistence of vitiligo and autoimmune thyroid disease.Currently,a-428 T FoxD3 variant is identified to be closely related to the occurrence of vitiligo,as well as increased levels of anti-thyroid peroxidase (TPO) antibodies and anti-thyroglobulin antibodies.