微小RNA在蕈样肉芽肿中的研究进展

蕈样肉芽肿是一种原发性皮肤T细胞淋巴瘤,临床表现多种多样,极易误诊.微小RNA(miRNA)是一种长约22个核苷酸的非编码小RNA,参与细胞分化、增殖、代谢、凋亡等生命活动,miRNA的功能失调对肿瘤的发生起作用.目前发现,一些miRNA在蕈样肉芽肿的发病、辅助诊断、判断预后起作用,并对蕈样肉芽肿的治疗具有潜在价值.如miR-155、miR-22、miR-150能促进蕈样肉芽肿的发病,miR-233、miR-200c则抑制蕈样肉芽肿.一组miRNA,miR-155、miR-203和miR-205,有助于鉴别诊断皮肤T细胞淋巴瘤和良性皮肤病.

Roles of microRNAs in mycosis fungoides

Mycosis fungoides (MF),a kind of primary cutaneous T cell lymphoma (CTCL) with various manifestations,is easy to misdiagnose.MicroRNAs (miRNAs) are a group of small non-coding RNA molecules of about 22 nucleotides in length,and participate in many biological processes,such as cell differentiation,proliferation,metabolism and apoptosis.Dysfunction of miRNAs is involved in the development of neoplasms.Studies have shown that some miRNAs play important roles in the pathogenesis,auxiliary diagnosis and prediction of prognosis of MF,and have potential value in the treatment of MF.For example,miR-155,miR-22 and miR-150 can promote the development of MF,while miR-233 and miR-200c can inhibit it.A group of miRNAs,including miR-155,miR-203 and miR-205,are considered to be helpful in distinguishing CTCL from benign skin diseases.