| 糖尿病肾病的表观遗传学机制 |
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| 引用本文： | 吴一鸣,杨震,秦利. 糖尿病肾病的表观遗传学机制[J]. 国际内分泌代谢杂志, 2017, 37(1). DOI: 10.3760/cma.j.issn.1673-4157.2017.01.14 |
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| 作者姓名： | 吴一鸣 杨震 秦利 |
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| 作者单位： | 200092,上海交通大学医学院附属新华医院内分泌科 |
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| 基金项目： | 上海市科学技术委员会科研计划项目(14ZR1427400)Scientific Research Plan of Shanghai Science and Technology Committee |
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| 摘 要： | 表观遗传学是指DNA序列不发生变化的情况下基因表达发生的可遗传的改变.大量的研究发现,表观遗传机制参与调控糖尿病肾病的肾脏纤维化、足细胞凋亡、慢性炎性反应、氧化应激等各个病理生理过程.
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| 关 键 词： | 糖尿病肾病 表观遗传学 调控 |
Epigenetic mechanism of diabetic nephropathy |
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| Wu Yiming,Yang Zhen,Qin Li. Epigenetic mechanism of diabetic nephropathy[J]. International JOurnal of Endocrinology and Metabolism, 2017, 37(1). DOI: 10.3760/cma.j.issn.1673-4157.2017.01.14 |
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| Authors: | Wu Yiming Yang Zhen Qin Li |
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| Abstract: | Epigenetics refers to the heritable alteration of gene expression without the change of DNA sequence.Emerging evidence from research suggests a key role for epigenetic mechanisms in the regulation of physiological and pathological processes of diabetic nephropathy including renal fibrosis,podocyte apoptosis,chronic inflammation,oxidant stress and so on. |
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| Keywords: | Diabetic nephropathy Epigenetics Regulation |
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