| 晚期糖基化终末产物及其受体与非酒精性脂肪性肝病的关系 |
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| 引用本文： | 李博,苏青. 晚期糖基化终末产物及其受体与非酒精性脂肪性肝病的关系[J]. 国际内分泌代谢杂志, 2017, 37(3). DOI: 10.3760/cma.j.issn.1673-4157.2017.03.013 |
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| 作者姓名： | 李博 苏青 |
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| 作者单位： | 200092,上海交通大学医学院附属新华医院内分泌科 |
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| 基金项目： | 国家自然科学基金资助项目，新华医院院基金(15YJ06)National Natural Science Foundation of China，Xinhua Hospital Foundation |
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| 摘 要： | 晚期糖基化终末产物(AGE)是高血糖的标志物,能通过AGE受体(RAGE)发挥致病作用.研究发现,AGE/RAGE与非酒精性脂肪性肝病(NAFLD)的发展关系密切.AGE能增加肝脏的甘油三酯水平,促进单纯性脂肪肝(SFL)的发生,AGE/RAGE可诱导肝脏炎性反应,促进SFL向非酒精性脂肪性肝炎(NASH)发展,并能通过诱导活性氧簇的合成,活化肝脏星状细胞来引起肝纤维化.
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| 关 键 词： | 晚期糖基化终末产物 晚期糖基化终末产物受体 非酒精性脂肪性肝病 |
Relationship between advanced glycation end-products and its receptor in nonalcoholic fatty liver diseases |
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| Li Bo,Su Qing. Relationship between advanced glycation end-products and its receptor in nonalcoholic fatty liver diseases[J]. International JOurnal of Endocrinology and Metabolism, 2017, 37(3). DOI: 10.3760/cma.j.issn.1673-4157.2017.03.013 |
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| Authors: | Li Bo Su Qing |
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| Abstract: | Advanced glycation end-products (AGE) are biomarkers of hyperglycemia,the receptors for AGE (RAGE) are involved in AGE-induced pathogenesis.It has found that AGE/RAGE was closely associated with the development of nonalcoholic fatty liver diseases (NAFLD).AGE can increase the accumulation of hepatic triglycerides and promote the occurrence of simple fatty liver (SFL).AGE/RAGE induces hepatic inflammation and accelerates the development of SLF to nonalcoholic steatohepatitis (NASH),and induces hepatic cirrhosis by promoting the synthesis of reactive oxygen species,activating hepatic stellate cells. |
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| Keywords: | Advanced glycation end-products Receptor for advanced glycation end-products Non-alcoholic fatty liver diseases |
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