| 骨钙素对青春发育的作用 |
| |
| 引用本文： | 吴美瑶,夏维波. 骨钙素对青春发育的作用[J]. 国际内分泌代谢杂志, 2017, 37(6). DOI: 10.3760/cma.j.issn.1673-4157.2017.06.009 |
| |
| 作者姓名： | 吴美瑶 夏维波 |
| |
| 作者单位： | 100730 北京,中国医学科学院,北京协和医学院,北京协和医院内分泌科,国家卫生和计划生育委员会(卫生部)内分泌重点实验室 |
| |
| 基金项目： | National Natural Science Foundation of China(81670714)国家自然科学基金资助项目 |
| |
| 摘 要： | 骨钙素影响睾酮的合成与分泌,因而亦会对男性青春发育的各方面产生影响,如性腺发育、精细胞凋亡及生长激增等,其在间质细胞上的相关受体及下游信号通路已得到了初步阐明.但尚未有证据支持骨钙素会对女性青春发育产生影响.同时,骨骼-睾丸正反馈系统的提出,对传统的下丘脑-垂体-性腺轴系统进行了补充,也为青春期相关疾病的研究和治疗提供了新的思路.
|
| 关 键 词： | 骨钙素 青春发育 下丘脑-垂体-性腺轴 |
Roles of osteocalcin in the development of puberty |
| |
| Wu Meiyao,Xia Weibo. Roles of osteocalcin in the development of puberty[J]. International JOurnal of Endocrinology and Metabolism, 2017, 37(6). DOI: 10.3760/cma.j.issn.1673-4157.2017.06.009 |
| |
| Authors: | Wu Meiyao Xia Weibo |
| |
| Abstract: | Osteocalcin has been proved to influence the synthesis and secretion of testosterone,and to play a unique role in male puberty development in many aspects,including gonadal development,spermatozoa apoptosis and growth spun.The receptor for osteocalcin which is expressed in leydig cells and its downstream signaling pathway have been identified.But there is no evidence to support osteocalcin will affect the female puberty development.The bone-testis positive feedback axis,a supplement to the traditional hypothalamic-pituitary-gonadal axis system,provides a new perspective on the research and treatment of puberty related disease. |
| |
| Keywords: | Osteocalcin Adolescent development Hypothalamic-pituitary-gonadal axis |
| 本文献已被 万方数据 等数据库收录！ |
|
