Association of Excess Weight and Degree of Airway Responsiveness in Asthmatics and Non-Asthmatics |
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| Authors: | Akshay Sood Steven J. Verhulst Adarsh Varma III Lanie E. Eagleton Joseph Q. Henkle Patricia Hopkins-Price |
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| Affiliation: | a From the Division of Pulmonary and Critical Care Medicine, University of New Mexico Health Sciences Center School of Medicine, Albuquerque, New Mexico, USAb From the Statistics and Research Consulting, Southern Illinois University School of Medicine, Springfield, Illinois, USAc University of Illinois at Chicago, Chicago, USAd From the Divisions of Pulmonary and Critical Care Medicine, Southern Illinois University School of Medicine, Springfield, Illinois, USA |
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| Abstract: | It is unclear whether obesity is associated with increasing degree of airway responsiveness in asthmatics. In this study, methacholine challenge test results of 1,725 subjects with respiratory symptoms were reviewed. Obesity was associated with asthma with an odds ratio of 1.72 (95% C.I. 1.36, 2.17). Although there was a significant difference in the degree of airway responsiveness between various body mass index categories of non-asthmatics (p = 0.01), no significant difference was noted among asthmatics (p = 0.93). A weakly significant interaction between asthma status and body mass index on the degree of airway responsiveness was noted (p = 0.08). |
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| Keywords: | asthma airway responsiveness methacholine challenge airway hyperreactivity obesity |
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