| 戈舍瑞林联合阿那曲唑作为一线内分泌方案治疗绝经前伴中、高危复发转移因素乳腺癌的临床研究 |
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| 引用本文： | 陈德滇,黄胜,周绍强,陈文林,杨庄青,张季,聂建云. 戈舍瑞林联合阿那曲唑作为一线内分泌方案治疗绝经前伴中、高危复发转移因素乳腺癌的临床研究[J]. 中国癌症杂志, 2011, 21(3). DOI: 10.3969/j.issn.1007-3969.2011.03.014 |
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| 作者姓名： | 陈德滇 黄胜 周绍强 陈文林 杨庄青 张季 聂建云 |
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| 作者单位： | 昆明医学院第三附属医院,云南省肿瘤医院乳腺治疗中心,云南省乳腺癌临床研究中心,云南昆明,650118 |
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| 摘 要： | 背景与目的:现已证实治疗绝经前乳腺癌患者,阿那曲唑疗效优于他莫昔芬,并有研究表明戈舍瑞林为安全有效的卵巢去势药物,然而两者联用作为乳腺癌内分泌治疗一线方案则鲜有报道.本研究旨在观察分析戈舍瑞林联合阿那曲唑作为绝经前伴中、高危复发转移因素的乳腺癌一线内分泌治疗临床疗效和预后.方法:分析本中心2002年至今应用戈舍瑞林联合阿那曲唑作为绝经前伴中、高危复发转移因素的68例乳腺癌患者一线内分泌治疗方案的疗效和预后:应用戈舍瑞林3.6 mg,每28 d皮下注射1次;阿那曲唑1 mg口服,每天1次;28 d为1个周期.所有患者按期评价疗效和不良反应.结果:68例患者中2例出现肿瘤复发转移,其余66例患者随访至今未出现肿瘤复发转移;中位治疗时间为3.6年,中位随访时间为48个月,无病生存率(disease-free survival,DFS)为97.1%,总生存率(overall survival,OS)为98.5%.结论:戈舍瑞林联合阿那曲唑治疗绝经前伴有中、高危复发转移因素乳腺癌疗效肯定,不良反应较轻,是一种有效的一线内分泌治疗药物.
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| 关 键 词： | 乳腺癌 内分泌治疗 阿那曲唑 芳香化酶抑制剂 戈舍瑞林 |
Anastrozole combined with goserelin in pre-menopausal patients with hormone dependent breast cancer inclined to recurrence and metastasis |
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| CHEN De-dian,HUANG Sheng,ZHOU Shao-qiang,CHEN Wen-lin,YANG Zhuang-qing,ZHANG Ji,NIE Jian-yun. Anastrozole combined with goserelin in pre-menopausal patients with hormone dependent breast cancer inclined to recurrence and metastasis[J]. China Oncology, 2011, 21(3). DOI: 10.3969/j.issn.1007-3969.2011.03.014 |
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| Authors: | CHEN De-dian HUANG Sheng ZHOU Shao-qiang CHEN Wen-lin YANG Zhuang-qing ZHANG Ji NIE Jian-yun |
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| Affiliation: | CHEN De-dian,HUANG Sheng,ZHOU Shao-qiang,CHEN Wen-lin,YANG Zhuang-qing,ZHANG Ji,NIE Jian-yun(Department of Breast,The Third Affiliated Hospital of Kunming Medical College,Yunnan Tumor Hospital,Kunming Yunnan 650118,China) |
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| Abstract: | Background and purpose:In postmenopausal patients,aromatase inhibitors have shown signi?cantly more bene?ts than tamoxifen.Ovarian-function suppression(goserelin) is safe and useful for suppressing ovarian function in premenopausal patients.The use of aromatase inhibitors in combination with ovarian-function suppression is currently under investigation in the premenopausal state.This study analyzed the clinical characteristics,disease-free survival(DFS),and overall survival(OS) when combined with anastrozol... |
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| Keywords: | Breast cancer Endocrine therapy Anastrozole Aromatase inhibitors Goserelin |
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