| 72例胃肠道间质瘤治疗的回顾性研究 |
| |
| 引用本文： | 葛晓明,孙晓光,梁正. 72例胃肠道间质瘤治疗的回顾性研究[J]. 中国癌症杂志, 2011, 21(3). DOI: 10.3969/j.issn.1007-3969.2011.03.012 |
| |
| 作者姓名： | 葛晓明 孙晓光 梁正 |
| |
| 作者单位： | 南京医科大学附属无锡第二医院普外科,江苏无锡,214002 |
| |
| 摘 要： | 背景与目的:胃肠道间质瘤(gastrointestinal stromal tumor,GIST)是一组起源于胃肠道肌层的间叶性肿瘤,以往外科手术是唯一治疗手段,随着CD117和CD34在肿瘤中表达的发现及分子靶向药物的出现,GIST的诊治有了重大进展.本研究回顾性分析72例手术治疗的GIST患者的临床资料,探讨GIST的诊断和治疗方法.方法:回顾性分析72例手术治疗的GIST患者的临床资料.术前采用消化内镜、B超及CT等影像学方法,所有患者予手术治疗,对其术后病理、临床诊断和治疗方法进行分析.结果:本组患者平均发病年龄为54.3岁.本病临床表现无特异性,常以腹部肿物和消化道出血为首发症状.消化内镜、B超及CT等检查可发现肿瘤,免疫标记物CD117、CD34在GIST中有较高表达,通过病理组织学及免疫组化检查可明确诊断.术后发生胃瘫5例,吻合口瘘2例,胰瘘1例,均经保守治疗后治愈或好转,平均随访时间为36个月.31例恶性间质瘤患者中有16例术后采用甲磺酸伊马替尼治疗(400 mg/d),其中4例复发,15例未作治疗的患者中有8例复发,差异有统计学意义(P<0.01).结论:CD117和CD34联合使用可协助鉴别诊断GIST.手术完整切除肿瘤仍然是首选治疗方法,分子靶向药物在新辅助治疗和术后辅助治疗中前景乐观.
|
| 关 键 词： | 胃肠道间质瘤 临床病理 免疫组织化学 |
Retrospective study of gastrointestinal stromal tumor |
| |
| GE Xiao-ming,SUN Xiao-guang,LIANG Zheng. Retrospective study of gastrointestinal stromal tumor[J]. China Oncology, 2011, 21(3). DOI: 10.3969/j.issn.1007-3969.2011.03.012 |
| |
| Authors: | GE Xiao-ming SUN Xiao-guang LIANG Zheng |
| |
| Affiliation: | GE Xiao-ming,SUN Xiao-guang,LIANG Zheng(Department of General Surgery,The 2nd Hospital of Wuxi,Nanjing Medical University,Wuxi Jiangsu 214002,China) |
| |
| Abstract: | Background and purpose:Gastrointestinal stromal tumor(GIST) originates from gastrointestinal muscular mesenchymal tissue.In the past,surgery was the only effective treatment method.However,diagnosis and treatment of GIST have made great progress since CD117 and CD34 were discovered in these tumors and molecular targeted drugs were found.This study retrospectively investigated the clinical diagnosis and treatment of 72 cases of GIST have undergone surgical treatment.Methods:The clinical data of the 72 GIST p... |
| |
| Keywords: | Gastrointestinal stromal tumor Clinicopathology Immunohistochemistry |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
