呼吸机相关性肺炎嗜麦芽窄食单胞菌感染的耐药性分析

目的:了解新生儿重症监护室(NICU)内呼吸机相关性肺炎(VAP)中嗜麦芽窄食单胞菌(SMA)感染的耐药情况,为指导临床合理用药提供依据.方法:采用MicroscanWalkAway 40全自动微生物分析仪进行细菌鉴定和药敏实验,对气管插管末端或吸痰管末端分离培养的16株SMA的耐药性进行监测.结果:SMA对亚胺培南、头孢曲松、头孢噻肟、庆大霉素的耐药率均在100%,左氧氟沙星、米诺环素、复方新诺明的耐药率(0%-18.7%)最低,替卡西林/棒酸耐药率较低(25%).结论:SMA为NICU内感染常见菌,耐药率高且易出现多重耐药,应根据药敏结果选取合适的抗生素.

Analysis of Drug Resistance of Stenotrophomonas Maltophilia in Newborn with Ventilator Associated Pneumonia

Objective： To study the drug resistance of stenotrophomonas maltophilia （SMA） in newborn with ventilator associated pneumonia（VAP）. Methods： 16 SMA trains were isolated from 16 newborns infected with SMA. API staphsystem and K-B agar diffusion method were used to identify the isolated SMA and to perform drug susceptibility testing. Results： 16 SMA trains were isolated.The drug-resistant rate to Imipeuem,Ceftriaxone, Cefotaxime and Gentamycin was 100%,and the rate to levofloxacin,minocycline, compound sulfame-thoxazole was low （0%-18.7%）, relatively low to ticarcillin/ca （25% ）. Conclusion： SMA has become important pathogen of VAP in NICU. The case of the antibiotic-resistant of SMA was serious. Drugs should be chosen based on sensitivity test results in clinical anti-infective therapy.