颈交感神经阻滞对放烧复合伤大鼠小肠组织血流量及ATP酶的影响

目的：探讨颈交感神经阻滞对放烧复合伤大鼠小肠组织血流量及ATP酶的影响。方法：SD大鼠接受5Gy^60Coγ射线全身性一次照射加TBSA15％Ⅲ度烧伤．随机分为复合伤对照组和复合伤加SB治疗组。检测不同时相点小肠黏膜、浆肌层组织血流量；肠黏膜Na^＋-K^＋-ATP酶、Ca^2＋-ATP酶活性。结果：放烧复合伤后7天内小肠黏膜和浆肌层血流量明显减少，肠黏膜Na^＋-K^＋-ATP酶、Ca^2＋-ATP酶活性急剧下降；SB治疗组较复合伤组小肠血液灌注量明显增加，同时Na^＋-K^＋-ATP酶、Ca^2＋-ATP酶活性增高。结论：SB可增加放烧复合伤大鼠小肠组织血液灌流，增加小肠黏膜ATP酶活性，改善肠道组织缺血缺氧和细胞能量代谢障碍。

Effect of SB on intestinal mucosal blood flow volume and ATPase from combined radiation and burn injury in rat

Objective:To investigate the effect of SB on intestinal mucosal blood flow volume and ATPase from combined radiation and burn injury in rat.Methods:Rat received a single 5 Gy dose of total body irradiation from 60Co gamma ray and TBSA15%III burn injury followed by treatment with SB or vehicle.Blood flow volume of intestinal mucosal and muscularis,Na+-K+-ATPase and Ca2+-ATPase activity were measured in different period.Results:Small intestinal mucosal and muscularis blood flow volume decreased significantly,Na+-K+-ATPase and Ca2+-ATPase activity decreased significantly in combined radiation and burn injury in rat in followed 7 days;SB administration caused increase in blood flow volume,Na+-K+-ATPase and Ca2+-ATPase activity as compared with combined radiation and burn injury group.Conclusion:SB can cause increase in blood flow volume and ATPase activity of small intestine in combined radiation and burn injury in rat,improve the ischemia,hypoxia and cellular energy metabolism in intestine.