| 半夏生物碱含量测定及止呕研究 |
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| 引用本文： | 王蕾,赵永娟,张媛媛,吴静芬,张向农,吉中强,岳旺. 半夏生物碱含量测定及止呕研究[J]. 中国药理学通报, 2005, 21(7): 864-867 |
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| 作者姓名： | 王蕾 赵永娟 张媛媛 吴静芬 张向农 吉中强 岳旺 |
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| 作者单位： | 1. 青岛大学医学院药理学教研室,山东,青岛,266021
2. 青岛市人民医院中医科,山东,青岛,266001 |
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| 基金项目： | 卫生部科研项目，山东省青岛市科技局资助项目 |
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| 摘 要： | 目的提取并测定半夏生物碱含量,研究其对水貂的止呕作用。方法提取半夏生物碱,采用酸性染料比色法测定含量;观察在顺铂(7.5mg·kg-1,ip)、阿朴吗啡(l.6mg·kg-1,sc)、硫酸铜(40mg·kg-1,ig)水貂呕吐模型的止呕作用;观察半夏生物碱对水貂运动呕吐模型(100r·min-1,1h)的影响。结果半夏生物碱含量为2.83mg·g-1,对顺铂、阿朴吗啡致水貂呕吐均有抑制作用(P<0.05),对硫酸铜及运动致水貂呕吐无效。结论半夏生物碱具止呕作用,其机制与中枢抑制有关。
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| 关 键 词： | 半夏 生物碱 呕吐 水貂 |
| 文章编号： | 1001-1978(2005)07-0864-04 |
| 修稿时间： | 2004-11-29 |
Determination of the total alkaloids of pinellia tuber and its anti-vomiting study in minks |
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| WANG Lei,ZHAO Yong-juan,ZHANG Yuan-yuan,WU Jing-fen,ZHANG Xiang-nong,JI Zhong-qiang,YUE Wang. Determination of the total alkaloids of pinellia tuber and its anti-vomiting study in minks[J]. Chinese Pharmacological Bulletin, 2005, 21(7): 864-867 |
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| Authors: | WANG Lei ZHAO Yong-juan ZHANG Yuan-yuan WU Jing-fen ZHANG Xiang-nong JI Zhong-qiang YUE Wang |
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| Abstract: | Aim To determine the alkaloids of pinellia tuber and to study its anti-emetic effects in minks. Method The alkaloid was tested by acid dye colorimetry; the effects of alkaloids of pinellia tuber on emesis model induced by cisplatin (7.5 mg·kg -1, ip), apomorphine(1.6 mg·kg -1, sc) or copper sulfate (40 mg·kg -1, ig) were studied; its effect on rotation-induced emesis model in minks was also observed. Results The content of alkaloids of pinellia tuber was 2.83 mg·g -1; pinellia tuber significantly inhibited the enesis model induced by cisplatin and apomorphine(P<0.05), while it could not resist the enesis induced by copper sulfate and rotation(P>0.05). Conclusion The alkaloids of pinellia tuber showed anti-emetic effect in minks. Its mechanism is probably related to its inhibiting property on central nervous system. |
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| Keywords: | pinellia tuber alkaloids emesis mink |
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