中药十八反“藻戟遂芫俱战草”的毒理学研究进展

中药“十八反”是在相反基础上形成的一组严格的配伍禁忌,然而从古至今临床应用反药治疗疾病的例子却层出不穷.反药是否相反,现代药性理论争议很多,并且也尚未形成较统一的判断标准和结论.通过查阅文献,从临床应用、制剂及给药方式、配伍比例、对P450酶系影响和毒理方面介绍了“十八反”中有关“海藻、大戟、甘遂、芫花反甘草”的研究现状,指出以往“藻戟遂芫俱战草”的研究,主要集中在急性毒性、长期毒性,对特定部位的实验研究还很少,并且存在药物基源、给药方式、配伍比例等实验条件不统一的现象,在此基础上提出应规范实验条件,降低各种不确定因素的影响,还应根据不同药物的作用特点从特定部位对海藻、大戟、甘遂、芫花配伍甘草进行系统研究,以期为藻戟遂芫伍甘草的准确用药和进一步深入研究提供文献基础.

Recent Advances in Toxicology Studies on Glycyrrhiza co-administered with Sargassum pallidum,Euphorbia pekinensis,Euphorbia kansui and Daphne genkwa

Eighteen incompatible pairs is a set of strict incompatibility formed at opposite basis, however, many combination of two incompatible herbs are applied in clinical to treat disease from the ancient time to today. Combination of two incompatible herbs are opposite or counter, there are many disputes in modern property theory, and has not formed a unified and objective judgment standard. Through the literature review, Glycyrrhiza co-administered with Sargassum pallidum, Euphorbia pekinensis, E.kansui and Daphne genkwa are introduced from the clinical application, preparation and administration, compatibility proportion,cytochrome P450 and toxicological aspects, pointing out that the past study of Glycyrrhiza co-administered with S.pallidum, E.pekinensis, E.kansui and D.genkwa focus on long-term toxicity, acute toxicity, and experimental study of specific site is very few, and experimental conditions are not unified phenomenon, such as drug source, mode of delivery, compatibility proportion.This paper presents that experimental conditions should be standardized to reduce all kinds of uncertain factors, and system study should be carried out based on the characteristics of different drugs from specific parts, in order to accurate medication of Glycyrrhiza co-administered with S.pallidum, E.pekinensis, E.kansui and D.genkwa and further research with literature foundation.