The association of circulating monocyte count with coronary collateral growth in patients with diabetes mellitus |
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Authors: | Sinan Altan Kocaman Asife Sahinarslan Ahmet Akyel Timur Timurkaynak Bulent Boyaci Atiye Cengel |
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Institution: | (1) Department of Cardiology, Gazi University School of Medicine, Besevler, 06500 Ankara, Turkey |
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Abstract: | The status of inflammation may affect the collateral development in patients with diabetes mellitus (DM). Monocytes were found
to have an important role in collateral growth in animal studies. We aimed to investigate the possible association of circulating
monocyte count with collateral development in patients with DM and severe coronary artery disease (CAD). We enrolled 134 consecutive
patients with DM who had ≥95 stenosis in at least one major coronary artery and investigated the relationship between circulating
monocyte count and collateral growth. When we analyzed the coronary angiograms of eligible patients, we found that 64 of them
had good collateral growth and 70 had poor collateral growth according to the Cohen–Rentrop method. The monocyte count was
significantly different between good and poor collateral growth groups (643 ± 184 vs. 479 ± 143 per mm3, P < 0.001). In the analysis comparing the Rentrop score with the Gensini score and circulating monocyte count, we found significant
correlations (r = 0.293, P = 0.001 and r = 0.455, P < 0.001, respectively). The duration of ischemic symptoms tended to be longer in the good collateral group (1.9 ± 4.1 vs.
0.8 ± 1.3 years, P = 0.079). The Gensini score was also correlated with the duration of myocardial ischemic symptoms (r = 0.299, P = 0.004). Multivariate analysis revealed an increased monocyte count in the good collateral group odds ratio (OR), 5.726; 95%
confidence interval (CI), 1.817–18.040, P = 0.003, the cut-off value for monocyte was defined as 550 cell/mm3]. The increased circulating monocyte count in diabetic patients was evidently related to good coronary collateral growth.
This finding may be potentially important in clinical and basic cardiovascular medicine. |
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