慢性肺心病降钙素基因相关肽内皮素心钠素的表达及其临床意义

目的 :探讨降钙素基因相关肽 (CGRP)内皮素 (ET)心钠素 (ANP)在慢性阻塞性肺疾病肺心病病理生理过程所起的作用、临床意义及其相互关系。方法 :应用放射免疫方法测定单纯慢性支气管炎(A组 ) 2 1例 ,慢性支气管炎并阻塞性肺气肿 (B组 ) 2 7例 ,慢性支气管炎、阻塞性肺气肿并肺心病 (PHD)(C组 ) 3 2例及健康对照组 (D组 ) 2 4例CGRP、ET及ANP水平 ,同步测定动脉血气及第一秒用力呼气容积占预计值的百分比数 (FEV1 %P)。结果 :1 各指标变化 ( 1)CGRPB、C组急性期、稳定期均低于对照组 ,且急性期均低于稳定期 ;C组各期相应的低于B组 ,A组急性期、稳定期与对照组无明显差异 ;( 2 )ETA组急性期及B、C组急性期、稳定期均高于对照组 ,各自组急性期均高于稳定期 ,除A组稳定期降至正常外 ,B、C组稳定期均高于对照组 ,且C组各期相应的高于B组 ;( 3 )ANPB组急性期及C组急性期、稳定期均高于对照组 ,C组急性期明显高于B组急性期 ,B、C组急性期明显高于各自稳定期。 2 直线相关分析结果 :CGRP与PaO2 呈非常显著正相关 (P <0 0 1) ,与PaCO2 、ANP呈显著负相关 (P <0 0 5 ) ,与ET呈非常显著负相关 (P <0 0 1) ;ET与ANP非常显著正相关 (P <0 0 1) ,与PaCO2 正相关 (P <0 0 5 ) ,与PaO2 、FEV1 %P非常显著负相关 (P

Plasma calcitonin gene-related peptide,endothelin and atrial natriuretic peptide and clinical significance in patients with chronic obstructive pulmonary disease and pulmonary heart disease

Objective:To explore the action and clinical significance of plasma calcitonin gene|related peptide (CGRP),endothelin (ET) and atrial natriuretic peptide (ANP) in patients with chronic obstructive pulmonary disease (COPD) and pulmonary heart disease (PHD).Method:Plasma CGRP, ET and ANP were measured by radioimmunoassay at different stages in 21 cases of chronic bronchitis (group A),in 27 cases of chronic bronchitis with obstructive pulmonary emphysema (group B),in 32 cases of chronic obstructive pulmonary emphysema with PHD (group C) and in 24 normal subjects (group D).Meanwhile,artery blood PaO-2,PaCO-2 and the first 1 second force expiratory volume possessing the percentage of the predicated value were also measured.Result:1.The plasma CGRP levels in acute exacerbation stage and stable stage of group B and group C were significantly elevated than that of control group ( P< 0^01).CGRP in acute exacerbation stage was higher than that in stable stages in both group B and group C ( P< 0^01).The plasma ET levels of acute exacerbation stages in group A,B,C and stable stages in group B,C were significantly higher than that of control group ( P< 0 01).ET in acute exacerbation stages was higher than that in stable stages in both group B and group C ( P< 0 01).The plasma ANP levels of group B,C in acute exacerbation stages and of group C in stable stages were higher than that of control group,respectively ( P< 0 01).The plasma ANP levels of group B,C in acute exacerbation stages were higher than that of group B,C in stable stages.2.Linear correlation analysis:The plasma CGRP level positively correlated with PaO-2 ( P< 0^01) and negatively correlation with PaCO-2,ANP and ET ( P< 0 05,0 05 and 0^01 respectively).The level of plasma ET was significantly positively correlated with ANP and PaCO 2 ( P< 0 01,0^05 respectively) and negatively correlated with PaO-2,FEV 1%P( P <0 01).The level of plasma ANP was negatively correlated with PaO-2 ( P< 0^01) and positively correlated with PaCO-2 ( P <0^01).Conclusion:The CGRP,ET and ANP participated in the pathophysiology changes and increase in pulmonary pressure in COPD and PHD.They correlated with the severity of the COPD and PHD and their secretion imbalance lead to the deterioration of the process of the disease. [