气功态时脑运动皮质低频活动同步性的静息fMRI研究

目的:通过观察气功师在气功态与非气功态,以及与非练功者之间脑运动皮质低频活动同步性的差异,探讨气功的本质及其对脑功能皮质的影响.材料和方法:研究对象为练功20年以上,以静功为主的气功师5名,以及相匹配年龄、性别并从未练过气功的对照5名.研究采用GE Signa VH/i 3.0T磁共振扫描机,先后进行无任务(静息态)和运动任务的BOLD序列扫描.通过计算运动皮质体素时间信号序列两两之间的交互相关系数以及平均交互相关系数(MCC),评价脑运动皮质低频信号的同步性.练功与非练功者,气功态与非气功态运动皮质的MCC值的差异用t检验进行评价.结果:所有被试者运动任务的fMRI检查均获得双侧运动皮质的明显激活.非练功者运动皮质的MCC值平均为0.20,练功者非气功态时MCC值平均为0.26,气功态时平均为0.40.经t检验非气功态时,练功者与非练功者脑运动皮质低频信号间的MCC值的差别无明显统计学意义,而练功者气功态与非气功态之间,练功者气功态与非练功者之间MCC值的差别有明显统计学意义,P＜0.01.结论:进入气功状态后,脑运动功能皮质低频活动的同步性会明显增强.但这种反映同步的相关系数是否可以作为其特征性的指标尚有待于进一步研究.

Resting-state fMRI Study of Low Frequency Synchrony in Motor Cortex under the State of "Qigong"

Purpose:To study the essence of qigong state and the effect of qigong on the functional brain cortex through the observing of the difference in low frequency synchrony in motor cortex between the qigong state and non-qigong resting-state,and between the qigong masters and the normal control volun-teers.Materials and Methods:5qigong masters and5control volunteers were tested in our study.The MRI machine was GE Signa VH/i3.0T.BOLD sequence was used for both the resting-state and Motor task fMRI studies.The cross-correlation coefficients of the low frequency time courses extracted were calculated,and mean cross-correlation coefficient(MCC)was used for the observation of the synchrony in the motor cortex.t-test was used for evaluating the difference of MCC values between the qigong masters and the normal control volunteers,and between the qigong state and non-qigong resting-state.Results:Functional location of the motor cortex was obtained in all objects from the motor task exam.From the normal control volunteer group,the mean value of MCC is0.20;from the non-qigong state master group it is0.26;and from the qigong state master group it is0.39.There is no significant statistic difference between MCC of motor cortex in normal control volunteer group and in non-qigong state master group.There is significant statistic difference between the MCC in normal control volunteer group and qigong state master group,and between non-qigong and qigong state master group.Conclusion:Under the state of qigong,the synchrony of the brain motor cortex was enhanced obviously.Whether the synchrony can be used as an index for the qigong state still needs further study.