Primary hepatic peripheral T-cell lymphoma associated with Epstein-Barr viral infection |
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Authors: | Daryl Ramai Emmanuel Ofori Sofia Nigar Madhavi Reddy |
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Affiliation: | Daryl Ramai, Emmanuel Ofori, Sofia Nigar, Madhavi Reddy, Division of Gastroenterology and Hepatology, Brooklyn Hospital Center, Brooklyn, NY 11201, United StatesDaryl Ramai, Department of Anatomical Sciences, St. George’s University School of Medicine, Grenada 999166, West Indies |
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Abstract: | Primary hepatic peripheral T-cell lymphoma(H-PTCL) is one of the rarest forms of non-Hodgkin lymphoma. We report a patient who presented with worsening jaundice, abdominal pain, and vomiting. Laboratory values were significant for elevated total bilirubin, alkaline phosphatase, and liver aminotransferases. Following a liver biopsy, histopathology revealed several large dense clusters of atypical T-lymphocytes which were CD2+, CD3+, CD5+, CD7-, CD4+, CD8-, CD56-, CD57-, CD30+ by immunohistochemistry. The proliferation index was approximately 70% by labeling for ki67/mib1. The above histological profile was consistent with peripheral T-cell lymphoma of the liver. Epstein-Barr viral serology indicated a remote infection, a likely risk factor for PTCL. Bone marrow biopsy was negative for malignancy, further supporting hepatic origin. |
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Keywords: | Primary lymphoma Liver cancer Non-Hodgkin’s lymphoma T-cell lymphoma |
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