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Association between genetic variants in the IL-23R gene and early-onset Crohn's disease: results from a case-control and family-based study among Canadian children |
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| Authors: | Amre Devendra K Mack David Israel David Morgan Kenneth Lambrette Philippe Law Liliane Grimard Guy Deslandres Colette Krupoves Alfreda Bucionis Vytautas Costea Irina Bissonauth Vishnee Feguery Houda D'Souza Savio Levy Emile Seidman Ernest G |
| Institution: | Department of Paediatrics, University of Montreal, Montreal, Canada;;Research Centre, Sainte-Justine Hospital, Montreal, Canada;;Division of Gastroenterology, Children's Hospital of Eastern Ontario, Ottawa, Canada;;Division of Gastroenterology, British Columbia's Children's Hospital, Vancouver, Canada;;Department of Human Genetics, McGill University Health Center, Montreal, Canada;;Division of Orthopedics, Department of Pediatrics, University of Montreal, Montreal, Canada;;Department of Preventive and Social Medicine, University of Montreal, Montreal, Canada;;Department of Nutrition, University of Montreal, Montreal, Canada;;and Faculty of Medicine, Division of Gastroenterology, McGill University Health Center, Montreal, Canada |
| Abstract: | BACKGROUND AND OBJECTIVES: Interleukin (IL)-23 is a key regulator of inflammation and influences the activities of T-helper 17 (Th-17) lymphocytes. Recent reports indicate that variants in the gene coding for its receptor (IL-23R) are strongly associated with Crohn's disease (CD). We investigated whether DNA variants in the IL-23R gene determine susceptibility for CD in Canadian children. DESIGN AND METHODS: A case-control and case-parent trio design was implemented at three pediatric centers across Canada. Cases of CD ( |
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