Inhibition of rat platelet aggregation by a Prudhoe Bay crude oil and its aliphatic,aromatic, and heterocyclic fractions |
| |
| Institution: | 1. Department of Biochemistry, Memorial University of Newfoundland, St. John''s, Newfoundland A1B 3X9, Canada;1. Department of Earth Sciences, Memorial University of Newfoundland, St. John''s, Newfoundland A1B 3X9, Canada;1. Key Laboratory of Carbon Materials, Institute of Coal Chemistry, Chinese Academy of Sciences, 27 South Taoyuan Road, Taiyuan 030001, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China;1. Institute of Organic and Polymeric Materials, National Taipei University of Technology, Taipei 10608, Taiwan;2. Department of Chemistry, National Central University, Chung-Li 32001, Taiwan;1. Department of Metallurgical and Materials Engineering, Faculty of Engineering and Architecture, Sinop University, 57000, Sinop, Turkey;2. Department of Chemistry and Chemical Administration Technologies, Yesilyurt Demir Celik Vocational School, Ondokuz Mayıs University, Tekkeköy, 55330, Samsun, Turkey;3. Department of Physics, Faculty of Arts and Sciences, Ondokuz Mayıs University, Kurupelit, 55139, Samsun, Turkey;4. Department of Molecular Biology and Genetics, Faculty of Science and Arts, Canik Basarı University, Gurgenyatak Campus, 55080, Samsun, Turkey;5. Department of Physics, Faculty of Arts and Sciences, Dokuz Eylül University, 35160, İzmir, Turkey;1. Department of Organic Chemistry, Indian Association for the Cultivation of Science, 2A & 2B Raja SC Mullick Road, Jadavpur, Kolkata 700032, India;2. Department of Materials Engineering, Indian Institute of Science, Bangalore 560012, India;3. Materials Research Center, Indian Institute of Science, Bangalore 560012, India;4. National Test House, Block-CP, Sector-V, Salt Lake, Kolkata 700091, India |
| |
| Abstract: | Wasjed platelets isolated from rats 24 hr after oral treatment with a Prudhoe Bay crude oil (PBCO) showed a substantial inhibition of aggregation induced by ADP, arachidonic acid, or epinephrine. In vitro addition of a dimethyl sulfoxide extract of PBCO or its aliphatic, aromatic, or heterocyclic fractions to washed platelets also resulted in an inhibition of aggregation. ADP release was inhibited in platelets to which an extract of PBCO or its fractions were added in vitro or in platelets isolated from rats treated in vivo with PBCO. Thromboxane B2 release was increased in platelets isolated from rats intubated with PBCO or in platelets to which a dimethyl sulfoxide extract of the aromatic or heterocyclic fraction was added. However, thromboxane B2 release was inhibited in platelets to which PBCO or the aliphatic fraction extracts were added. The results indicate that PBCO inhibits platelet aggregation presumably by bringing about alterations in the platelet plasma membrane. Inhibition of ADP release could contribute to the inhibition of aggregation but thromboxane B2 is believed not to play a significant role. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
