Highly efficient synthesis of 3,4-diarylbutadiene sulfones using Heck–Matsuda reaction |
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Authors: | Olga V. Shurupova Sergey A. Rzhevskiy Lidiya I. Minaeva Maxim A. Topchiy Andrey F. Asachenko |
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Affiliation: | A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Leninsky Prospect 29, Moscow 119991 Russia, |
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Abstract: | For the first time we describe a general method for the synthesis of previously not synthesized unsymmetrical 3,4-diarylbutadiene sulfones which can be stable convenient precursors for 2,3-diaryl-1,3-butadienes. Our method for arylation of butadiene sulfones via Heck–Matsuda reaction allows to obtain unsymmetrical 3,4-diarylbutadiene sulfones with a variety of alkyl, alkoxy, nitro, ethoxycarbonyl, perfluoroalkyl and halogen substituents (30 examples) in very good yields using readily available reagents and catalysts.An efficient and facile Pd-catalyzed synthesis of 3,4-diarylbutadiene sulfones with high regioselectivity from aryldiazonium salts and butadiene sulfone was developed. |
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