30例食管癌适形放疗疗效观察

目的探讨食管癌适形放疗的临床疗效，分析患者的急性放射性损伤情况，为适形放疗的临床应用提供参考。方法选择2006年1月-2009年12月我院收治的30例食管癌患者进行三维适形放疗，随机挑选30例食管癌患者作为对照组进行常规放疗。对两组患者1—3年生存率及急性放射性损伤情况进行随访观察和分析。结果两组患者1年生存率、2年生存率差异均无统计学意义（P〉0.05）。适形放疗组患者的3年生存率显著高于对照组（P〈0.05）。两组患者均顺利完成整个化疗进程。适形放疗组患者有2例发生Ⅰ级食管放射损伤，1例发生Ⅱ级食管放射损伤，1例发生Ⅲ级食管放射损伤，1例发生肺部放射损伤，未有患者发生放射性肺炎，有4例患者发生放射性气管炎，适形放疗组患者的急性放射性损伤发生率较低，但两组患者的急性放射性损伤发生率差异无统计学意义。结论三维适形放疗可提高食管癌患者的生存率，并减少放疗的损伤，更有利于患者的接受。

Effect Analysis of 30 Cases of Esophageal Cancer Using Conformal Radiotherapy

Objective To investigate the clinical efficacy of esophageal cancer with conformal radiotherapy, analyze acute radioactive injury of patients and provides a useful reference for clinical application of conformal radiotherapy. Methods 30 cases of esophageal carcinoma in January 2006 to December 2009 in our hospital were enrolled to have three-dimensional conformal radiotherapy, and we randomly selected 30 cases of esophageal cancer patients as a control group for conventional radiotherapy. 1-3 year survival rate and acute radiation injury of two groups of patients were observed and analyzed. Results 1 year survival rate of conformal radiotherapy group patients was 73.3%, 2 years survival rate was 54.2%, and 3 years survival rate of 43.8%. 1 year survival rate and 2 years survival rate of two groups had no statistical significance（P〉0.05）. The 3 years survival rate of conformal radiotherapy group was significantly higher than that of control group（P〈0.05）. Two groups of patients were successfully completed in the chemotherapy process. Conformal radiotherapy patients had 2 cases of Ⅰ grade esophageal radiation injury, 1 cases of Ⅱ grade esophageal radiation injury, 1 cases of Ⅲ grade esophageal radiation injury, 1 cases of pulmonary radiation /njury, and did not had patients with radiation pneumonitis. 4 cases had tracheitis of radiation injury. The incidence of acute radioactive injury of conformal radiotherapy was low, but the acute radioactive injury incidence differences of two groups of patients were not statistically significant. Conclusion Three-dimensional conformal radiotherapy could improve the survival rate of patients with esophageal carcinoma, and reduce the radiation damage, and it was more advantageous to the patient to accept.