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Whole-body diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient mapping for staging patients with diffuse large B-cell lymphoma
Authors:Chieh Lin  Alain Luciani  Emmanuel Itti  Taoufik El-Gnaoui  Alexandre Vignaud  Pauline Beaussart  Shih-jui Lin  Karim Belhadj  Pierre Brugières  Eva Evangelista  Corinne Haioun  Michel Meignan  Alain Rahmouni
Affiliation:1. Imagerie Médicale, AP-HP, Groupe Henri-Mondor Albert-Chenevier, CHU Henri Mondor, 51 Avenue du Malréchal de Lattre de Tassigny, 94010, Créteil, France
2. Université Paris-Est Créteil Val de Marne, Faculté de Médecine, 94010, Créteil, France
4. INSERM Unité U955, Equipe 17, 94010, Créteil, France
3. CNRS, UMR7054, 94010, Créteil, France
5. Médecine Nucléaire, AP-HP, Groupe Henri-Mondor Albert-Chenevier, CHU Henri Mondor, 51 Avenue du Malréchal de Lattre de Tassigny, 94010, Créteil, France
6. Hématologie Clinique, AP-HP, Groupe Henri-Mondor Albert-Chenevier, CHU Henri Mondor, 51 Avenue du Malréchal de Lattre de Tassigny, 94010, Créteil, France
7. Siemens Healthcare, 9 Boulevard Finot, 93527, Saint-Denis, France
8. Department of Statistics, Stanford University, 450 Serra Mall, Stanford, CA, 94305, USA
Abstract:

Objective

To design a whole-body MR protocol using exclusively diffusion-weighted imaging (DWI) with respiratory gating and to assess its value for lesion detection and staging in patients with diffuse large B-cell lymphoma (DLBCL), with integrated FDG PET/CT as the reference standard.

Methods

Fifteen patients underwent both whole-body DWI (b?=?50, 400, 800 s/mm2) and PET/CT for pretreatment staging. Lymph node and organ involvement were evaluated by qualitative and quantitative image analysis, including measurement of the mean apparent diffusion coefficient (ADC).

Results

A total of 296 lymph node regions in the 15 patients were analysed. Based on International Working Group size criteria alone, DWI findings matched PET/CT findings in 277 regions (94%) (kappa score?=?0.85, P?Conclusion Whole-body DWI with ADC analysis can potentially be used for lesion detection and staging in patients with DLBCL.
Keywords:
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