Antiproliferative oleanane saponins from Meryta denhamii |
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| Authors: | Cioffi Giuseppina Dal Piaz Fabrizio Vassallo Antonio Venturella Fabio De Caprariis Paolo De Simone Francesco De Tommasi Nunziatina |
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| Affiliation: | Dipartimento di Scienze Farmaceutiche, Universitaàdi Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy. |
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| Abstract: | Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164. |
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