Spotsize effects on guinea pig skin following pulsed irradiation

Laser irradiation parameters such as wavelength, irradiance (W/cm2), and pulse duration have been clearly shown to influence the extent to which tissue is damaged. The careful choice of these parameters can result in confining laser injury to specific targets in tissue. Spotsize, a parameter not commonly appreciated in the application of lasers to medicine and surgery, has been shown, in this study, to contribute to the ultimate outcome of laser effects in tissue. A series of histological events occurring in the skin are demonstrated to be directly related to the effects of spotsize on tissue at a fixed exposure time and wavelength. Many of these changes could contribute to unwanted adverse effects, such as scarring, which occur following certain laser therapies.