Psychoneurodendocrine correlates of lymphocyte subsets during healthy ageing |
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Authors: | Collaziol Diego Luz Clarice Dornelles Fabiana da Cruz Ivana M Bauer Moisés Evandro |
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Institution: | Instituto de Pesquisas Biomédicas, S?o Lucas Hospital, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS 90610-000, Brazil. |
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Abstract: | Ageing has been associated with increased cortisol levels and absolute counts of T lymphocytes with memory phenotype. Although the mechanisms underlying these changes are still unknown, it has been speculated that this could be related to a dysfunction in FAS/CD95 expression in naive or memory cells. In this study, we investigated the role of psychoneuroendocrine variables in regulating CD95 expression on lymphocyte subsets. Forty-six elderly subjects (65-91 years) and 33 young adults (20-40 years) were recruited accordingly the SENIEUR protocol. The psychological status was measured by structured clinical interviews, salivary cortisol was assessed along the day (9, 12 and 22h) and peripheral blood lymphocytes were immunophenotyped. The elderly were more stressed, depressed and anxious than the young subjects. Cortisol levels were increased in the elderly, indicating an activation of the hypothalamic-pituitary-adrenal (HPA) axis. We observed reduced counts of CD45RA+CD95+ cells in the elderly compared to young adults. The elderly subjects also showed a reduced expression of CD3 and CD62L in contrast to increased CD95 expression in CD45RA+ cells. The emotional state was positively correlated with the lymphocyte markers. Our data suggest the healthy ageing is associated with psychoneuroendocrine alterations that may be implicated in the regulation of CD95 expression on peripheral T cells. |
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Keywords: | CD95 Immunosenescence Ageing Psychoneuroimmunology Glucocorticoids Psychological stress Lymphocytes |
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