| Abstract: | Experiments on male Wistar rats showed that 6–12 h after a single injection of haloperidol in a dose of 1 mg/kg the intensity of apomorphine stereotypy increased gradually, to exceed the control level after 24 h. After injection of this neuroleptic the intensity of apomorphine stereotypy showed negative correlation with the homovanillic acid concentration in the rats' forebrain. It is suggested that the homovanillic acid concentration reflects the sensitivity of dopamine receptors to agonists.Laboratory of Psychopharmacology and Department of Pharmacology, Tartu University. (Presented by Academician of the Academy of Medical Sciences of the USSR, S. V. Anichkov). Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 87, No. 6, pp. 559–560, June, 1979. |
