慢性肝病患者血清和腹水肿瘤坏死因子及白细胞介素8的变化

目的 探讨慢性肝病患者血清和腹水肿瘤坏死因子(TNF)和白细胞介素8(IL-8)水平对细菌感染的诊断价值。方法 对双抗体夹心酶联免疫法(ELISA)检测32例慢性肝病患者血清和腹水TNF和IL-8水平。结果 慢性肝病合并感染组血清TNF和IL-8水平显著高于正常对照组(P<0.05)及无感染组(P<0.01);慢性肝病患者合并自发性细菌性腹膜炎(SBP)组血清和腹水TNF和IL-8水平明显高于无SBP组(P<0.01);死亡组患者最初血清和腹水TNF和IL-8水平明显高于存活组(P<0.05)。结论 测定慢性肝病患者血清和腹水TNF和IL-8水平对判断细菌感染的诊断和病情观察有一定的临床价值。

THE CHANGE AND ITS SIGNIFICANCE OF SERUM AND ASCITIC LEVELS OF TUMOR NECROSIS FACTOR AND INTERLEUKIN-8 IN PATIENTS WITH CHRONIC LIVER DISEASES

Objective To assess the changes of scrum and ascitic levels of TNF and IL-8 in patients with chronic liver diseases. Methods Serum and ascitic levels of TNF and IL-8 were detected by ELISA in 32 patients with chronic liver diseases. Results The serum levels of both TNF and IL-8 were higher in patients with bacterial infections than in normal controls or in patients without infection ( P <0.01).The increase of serum and ascitic levels of TNF and IL-8 were more obvious in patients who died than those survived. Conclusions These findings suggest that detection of serum and ascitic TNF and IL-8 levels is helpful in determining the presence of bacterial infections in patients with chronic liver diseases.