| Abstract: | Objective To study the expression of p16, cyclin D1, Rb and phosphorylated Rb(Ser795) in the esophageal squamous cell carcinoma. Methods Immunohistochemistry was performed and analysed on 34 cases of paraffin-embedded tissues. Results The expression of phosphorylated Rb(Ser795) was positively correlated to that of cyclin D1 (r=0.401, P=0.021) and inversely to that of p16 (r=-0.348, P=0.044). In stepwise regression and the best subset regression, the expression of p16 (P=0.034) and phosphorylated Rb(Ser795) (P=0.030) were the only determinants of the mitotic index. Conclusion The expression of phosphorylated Rb(Ser795) could be considered as a mark of the interaction between p16 and cyclin D1. The detection of phosphorylated Rb, p16 and cyclin D1 will be possibly helpful to the oncogenesis investigation on the esophageal carcinoma. |
