Effects of ethyl-CPIB (clofibrate) on tissue lipoprotein lipase and plasma post-heparin lipolytic activity in rats |
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| Authors: | J M Odonkor M P Rogers |
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| Affiliation: | Department of Biochemistry, The University, Newcastle upon Tyne NE1 7RU, U.K. |
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| Abstract: | The role of LPL in reducing the serum triacylglycerol concentration was investigated in rats fed a high sucrose diet containing 0.25% (w/w) ethyl-CPIB. Compared with sucrose-fed controls, drug treatment resulted in a fall in adipose tissue LPL activity and a rise in enzyme activity in thigh and heart muscle. Serum post-heparin lipoprotein lipase activity after a high dose of heparin was lower in ethyl-CPIB-treated rats than controls, but after a low dose of heparin the values were similar. The amount of LPL activator was decreased by the drug. Thus, the low serum triacylglycerol concentration observed in the ethyl-CPIB-treated rats cannot be explained by changes in functional LPL activity. The plasma triacylglycerol-lowering effect of the drug could be explained by the observed decrease in triacylglyerol output by the liver. |
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| Keywords: | HDL, high density lipoprotein LDL, low density lipoprotein LPL, lipoprotein lipase PHLA, post-heparin lipolytic activity VLDL, very low density lipoprotein |
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